1227161-00-3

Basic information

• Product Name: methyl 4-(2-ethoxy-1,1-difluoro-2-oxoethyl)benzoate
• Synonyms: methyl 4-(2-ethoxy-1,1-difluoro-2-oxoethyl)benzoate
• CAS NO: 1227161-00-3
• Molecular Weight: 258.222
• Mol File: 1227161-00-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: methyl 4-(2-ethoxy-1,1-difluoro-2-oxoethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(2-ethoxy-1,1-difluoro-2-oxoethyl)benzoate(1227161-00-3)
• EPA Substance Registry System: methyl 4-(2-ethoxy-1,1-difluoro-2-oxoethyl)benzoate(1227161-00-3)

Safety Data

• Hazardous Substances Data: 1227161-00-3(Hazardous Substances Data)

Upstream product

• 7648-30-8 ethyl 2,2-difluoro-2-iodoacetate 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 667-27-6 Ethyl bromodifluoroacetate 
• 619-44-3 methyl 4-iodobenzoate 
• 93-58-3 benzoic acid methyl ester 
• 383-62-0 ethyl 2-chloro-2,2-difluoroacetate 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 98-88-4 benzoyl chloride 

Relevant articles and documents

Pd-Catalyzed para-selective C-H difluoromethylation of aromatic carbonyls

A novel palladium catalyzed highly para-selective C-H difluoromethylation of electron-deficient aromatic carbonyls was developed. Diverse substituted aromatic ketones and benzoates were selectively difluoromethylated at the remote para-site of carbonyl gr

A Metallaphotoredox Strategy for the Cross-Electrophile Coupling of α-Chloro Carbonyls with Aryl Halides

Here, we demonstrate that a metallaphotoredox-catalyzed cross-electrophile coupling mechanism provides a unified method for the α-arylation of diverse activated alkyl chlorides, including α-chloroketones, α-chloroesters, α-chloroamides, α-chlorocarboxylic acids, and benzylic chlorides. This strategy, which is effective for a wide variety of aryl bromide coupling partners, is predicated upon a halogen atom abstraction/nickel radical-capture mechanism that is generically successful across an extensive range of carbonyl substrates. The construction and use of arylacetic acid products have further enabled two-step protocols for the delivery of valuable building blocks for medicinal chemistry, such as aryldifluoromethyl and diarylmethane motifs.

Copper-mediated aerobic fluoroalkylation of arylboronic acids with fluoroalkyl iodides at room temperature

A Cu-mediated ligandless aerobic fluoroalkylation of arylboronic acids under mild conditions is described for the first time. The reaction tolerates a wide range of functional groups, allowing for further transformation. Mechanistic studies suggest that [RfCu] is the active Cu species that forms the desired perfluoroalkylarenes and that [RfCu] is generated from [PhCu] by either an oxidative addition/reductive elimination mechanism or nucleophilic substitution via a halogen "ate" intermediate.