122745-41-9

Basic information

• Product Name: 3-(tert-butyloxycarbonyl)-1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzindole
• Synonyms: 3-(tert-butyloxycarbonyl)-1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzindole
• CAS NO: 122745-41-9
• Molecular Weight: 333.815
• Mol File: 122745-41-9.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 3-(tert-butyloxycarbonyl)-1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzindole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(tert-butyloxycarbonyl)-1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzindole(122745-41-9)
• EPA Substance Registry System: 3-(tert-butyloxycarbonyl)-1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzindole(122745-41-9)

Safety Data

• Hazardous Substances Data: 122745-41-9(Hazardous Substances Data)

Upstream product

• 122745-39-5 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-1,2-dihydro-3H-benzindole 
• 128300-09-4 (+)-(1S)-5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-1,2-dihydro-3H-benzindole 
• 5959-56-8 4-amino-1-naphthol hydrochloride 
• 13802-40-9 1-Methoxy-3-nitronaphthalene 
• 685143-01-5 5-(4-benzyloxy-2-nitronaphthalen-1-yl)-2,2-dimethyl[1,3]dioxane 
• 685143-02-6 [4-benzyloxy-1-(2,2-dimethyl[1,3]dioxan-5-yl)naphthalen-2-yl]amine 
• 685142-82-9 1-(acetylamino)-4-benzyloxy-2-nitronaphthalene 
• 685142-83-0 4-(benzyloxy)-2-nitronaphthalen-1-amine 
• 685142-86-3 4-benzyloxy-1-chloro-2-nitronaphthalene 
• 685143-09-3 1-(acetylamino)-4-hydroxy-2-nitronaphthalene 
• 98728-71-3 4-acetoxy-1-(acetylamino)naphthalene 
• 20032-84-2 4-acetoxy-1-(acetylamino)-2-nitronaphthalene 
• 24424-99-5 di-tert-butyl dicarbonate 
• 685142-94-3 (-)-(1S)-N-(tert-butyloxycarbonyl)-1-hydroxymethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole 

Relevant articles and documents

Synthesis of N-(tert-Butyloxycarbonyl)-CBI, CBI, CBI-CDPI1, and CBI-CDPI2: Enhanced Functional Analogues of CC-1065 Incorporating the 1,2,9,9a-Tetrahydrocyclopropabenzindol-4-one (CBI) Left-Hand Subunit

Full details of the synthesis of N-(tert-butyloxycarbonyl)-1,2,9,9a-tetrahydrocyclopropabenzindol-4-one constituting a more stable functional analogue of the CC-1065 left-hand subunit are described.The resolution of an immediate CBI

Bifunctional cytotoxin and application thereof

The invention provides a bifunctional cytotoxin containing a duocarmycin analogue and a nitrogen mustard compound, and further provides an antibody drug conjugate coupled with the bifunctional cytotoxin and pharmaceutical application of the antibody drug

Bifunctional cytotoxic agents

Cytotoxic dimers comprising CBI-based and/or CPI-based sub-units, antibody drug conjugates comprising such dimers, and to methods for using the same to treat cancer and other conditions.

ASYMMETRIC CONJUGATE COMPOUNDS

The invention relates to compound of formula (I): A-X1-L-X2-B and salts, solvates and tautomers thereof, which are useful as medicaments, in particular as anti-proliferative agents and for use as a drug in an antibody-drug conjugate;