128228-76-2

Upstream product

• 51019-43-3 (R)-(-)-O-acetylmandelic acid 
• 122745-39-5 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-1,2-dihydro-3H-benzindole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 19256-80-5 3-Nitro-1-naphthol 
• 13802-40-9 1-Methoxy-3-nitronaphthalene 
• 100-39-0 benzyl bromide 
• 122745-35-1 3-Amino-1-(benzyloxy)naphthalene 
• 122745-36-2 N-(tert-butyloxycarbonyl)-4-(benzyloxy)-2-naphthylamine 
• 122745-37-3 2-((tert-Butyloxycarbonyl)amino)-4-(benzyloxy)-1-bromonaphthalene 
• 122745-38-4 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-methylidene-1,2-dihydro-3H-benzindole 
• 122745-45-3 N-(tert-butyloxycarbonyl)-N-(2-propynyl)-4-(benzyloxy)-1-bromo-2-naphthylamine 

Downstream Products

• 122745-41-9 tert-butyl (1S)-1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzo[e]indole-3-carboxylate 
• 128300-11-8 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-1,2-dihydro-3H-benzindole 
• 128300-15-2 (+)-CBI-CDPI2 
• 128300-09-4 (+)-(1S)-5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-1,2-dihydro-3H-benzindole 

Relevant academic research and scientific papers

Synthesis of N-(tert-Butyloxycarbonyl)-CBI, CBI, CBI-CDPI1, and CBI-CDPI2: Enhanced Functional Analogues of CC-1065 Incorporating the 1,2,9,9a-Tetrahydrocyclopropabenzindol-4-one (CBI) Left-Hand Subunit

Full details of the synthesis of N-(tert-butyloxycarbonyl)-1,2,9,9a-tetrahydrocyclopropabenzindol-4-one constituting a more stable functional analogue of the CC-1065 left-hand subunit are described.The resolution of an immediate CBI

Resolution of a CBI precursor and incorporation into the synthesis of (+)-CBI, (+)-CBI-CDPI1, (+)-CBI-CDPI2: Enhanced functional analogs of (+)-CC-1065. A critical appraisal of a proposed relationship between electrophile reactivity,

Details of the resolution of an immediate CBI precursor, (+)- and (-)-8, and its subsequent incorporation into (+)- and (-)-CBI-CDPI(n), optically-active enhanced functional analogs of (+)-CC-1065, are described. In marked contrast to a previously detaile