1228-88-2 Usage
Chemical classification
1H-Purine-2,6-dione,
8-chloro-3,7-dihydro-3,7-dimethyl-1-(phenylmethyl)- belongs to the purine family and is a heterocyclic compound with a purine ring structure.
Structure
It has a chlorine atom attached to the 8th position and a phenylmethyl group attached to the 1st position. It also has two methyl groups attached to the 3rd and 7th positions.
Biological and pharmacological properties
1H-Purine-2,6-dione,
8-chloro-3,7-dihydro-3,7-dimethyl-1-(phenylmethyl)- has potential biological and pharmacological properties and has been studied for its potential use in the treatment of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD).
Medical use
It is used in the pharmaceutical industry as a bronchodilator and smooth muscle relaxant.
Other potential uses
1H-Purine-2,6-dione,
8-chloro-3,7-dihydro-3,7-dimethyl-1-(phenylmethyl)- has also been explored for its potential use as an anti-inflammatory and immunomodulatory agent.
Check Digit Verification of cas no
The CAS Registry Mumber 1228-88-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,2,2 and 8 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1228-88:
(6*1)+(5*2)+(4*2)+(3*8)+(2*8)+(1*8)=72
72 % 10 = 2
So 1228-88-2 is a valid CAS Registry Number.
1228-88-2Relevant academic research and scientific papers
MLKL INHIBITORS
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, (2018/09/26)
Purine derivatives that inhibit cellular necroptosis and/or human MLKL, pharmaceutical compositions thereof, and methods of treating an MLKL-mediated disorder with an effective amount of the compound or composition. Said MLKL-mediated disorder is pathology associated necroptosis, including ischemia-reperfusion damage, neurodegeneration, and inflammatory diseases such as acute pancreatitis, multiple sclerosis, inflammatory bowel disease, and allergic colitis.
