1228372-45-9Relevant academic research and scientific papers
Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction
Herath, Ananda,Cosford, Nicholas D. P.
, p. 239 - 246 (2017)
A versatile continuous-flow synthesis of highly functionalized 1,2,4-oxadiazoles starting from carboxylic acids is reported. This process was applied to the multistep synthesis of imidazo[1,2-a]pyridin-2-yl-1,2,4-oxadiazoles, using a three reactor, multistep continuous-flow system without isolation of intermediates. This continuous-flow method was successfully combined with a single-step liquid-liquid microextraction unit to remove high boiling point polar solvents and impurities and provides the target compounds in high purity with excellent overall yields.
IMIDAZO [1,2A] PYRIDINE DERIVATIVES, THEIR USE AS S1P1 AGONISTS AND METHODS FOR THEIR PRODUCTION
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Page/Page column 125-126, (2010/06/20)
The invention is directed to Compounds of Formula (I) as well as methods of making and using the compounds.
