1228837-05-5 Usage
Description
4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde is an organic compound characterized by its unique chemical structure, which features a biphenyl core with a chloro substituent at the 4' position and two methyl groups at the 5,5 positions. The compound also contains a tetrahydro ring and a formyl group at the 2 position, which contributes to its reactivity and potential applications in various chemical and pharmaceutical processes.
Uses
Used in Pharmaceutical Industry:
4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde is used as an intermediate in the synthesis of various pharmaceutical compounds for the treatment of cancer and immune and autoimmune diseases. Its unique structure allows it to be a key component in the preparation of N-(phenylsulfonyl)benzamides and N-(3-pyridylsulfonyl)benzamides, which are known for their apoptosis-inducing properties.
Used in Chemical Synthesis:
In the chemical industry, 4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde can be utilized as a versatile intermediate in the synthesis of a wide range of compounds. Its reactivity and functional groups make it a valuable building block for creating new molecules with potential applications in various fields, such as materials science, agrochemicals, and specialty chemicals.
Used in Research and Development:
Due to its unique chemical structure and potential reactivity, 4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde can be employed in research and development efforts to explore new chemical reactions, synthetic pathways, and potential applications. Its use in academic and industrial research can lead to the discovery of novel compounds and technologies with significant impact on various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 1228837-05-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,2,8,8,3 and 7 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1228837-05:
(9*1)+(8*2)+(7*2)+(6*8)+(5*8)+(4*3)+(3*7)+(2*0)+(1*5)=165
165 % 10 = 5
So 1228837-05-5 is a valid CAS Registry Number.
1228837-05-5Relevant articles and documents
Mild and Robust Stille Reactions in Water using Parts Per Million Levels of a Triphenylphosphine-Based Palladacycle
Takale, Balaram S.,Thakore, Ruchita R.,Casotti, Gianluca,Li, Xaiohan,Gallou, Fabrice,Lipshutz, Bruce H.
supporting information, p. 4158 - 4163 (2021/02/01)
An inexpensive and new triphenylphosphine-based palladacycle has been developed as a pre-catalyst, leading to highly effective Stille cross-coupling reactions in water under mild reaction conditions. Only 500–1000 ppm of Pd suffices for couplings involving a variety of aryl/heteroaryl halides with aryl/hetaryl stannanes. Several drug intermediates can be prepared using this catalyst in aqueous nanoreactors formed by 2 wt % Brij-30 in water.
1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS BCL-2 INHIBITORS FOR THE TREATMENT OF NEOPLASTIC AND AUTOIMMUNE DISEASES
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Page/Page column 150-151, (2021/07/02)
The present invention relates to lH-pyrrolo[2,3-b]pyridine derivatives and related compounds as BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 162 to 233; examples 1 to 8; table; compound examples cpd-1 to cpd-135; biological examples 1 to 4).
BCL-2 INHIBITORS AND THEIR USE AS PHARMACEUTICALS
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Paragraph 0451-0452, (2021/11/13)
The disclosure is directed to, in part, to BCL-2 inhibitors, pharmaceutical compositions comprising the same, as well as methods of their use and preparation.
