1232006-56-2

Basic information

• Product Name: p-methoxypyridine
• Synonyms: p-methoxypyridine
• CAS NO: 1232006-56-2
• Molecular Formula: C6H7NO
• Molecular Weight: 109
• Mol File: 1232006-56-2.mol
• Article Data: 55

Chemical Properties

• Appearance: /
• CAS DataBase Reference: p-methoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: p-methoxypyridine(1232006-56-2)
• EPA Substance Registry System: p-methoxypyridine(1232006-56-2)

Safety Data

• Hazardous Substances Data: 1232006-56-2(Hazardous Substances Data)

Upstream product

• 626-61-9 4-Chloropyridine 
• 124-41-4 sodium methylate 
• 93560-55-5 2-iodo-3-methoxy-pyridine 
• 82257-09-8 bromo-3 methoxy-4 pyridine 
• 40473-07-2 6-bromo-2-methoxypyridine 
• 142929-26-8 4-Methoxy-3-(trimethylstannyl)pyridin 
• 130671-15-7 1-(2-Cyano-ethyl)-4-methoxy-pyridinium; bromide 
• 1089100-76-4 trichloro(4-methoxypyridine)gold(III) 
• 16887-00-6 chloride 
• 186581-53-3 diazomethane 
• 67-56-1 methanol 
• 26708-23-6 trans-[4-(4'-dimethylaminostyryl)]pyridine N-oxide 
• 96245-98-6 2,3-dibromo-4-methoxypyridine 
• 74414-99-6 N-(methoxycarbonyl)-4-methoxypyridinium ion 

Downstream Products

• 126378-84-5 (RS)-2-phenyl-2,3-dihydro-1H-pyridin-4-one 
• 56898-50-1 4-methoxypyridine borane complex 
• 136025-20-2 1-amino-4-methoxypyridin-1-ium 2,4,6-trimethylbenzenesulfonate 
• 1253390-72-5 1-(2-(allyl(tert-butoxycarbonyl)amino)-4-(benzyloxy)-6-formylpyrido[2,3-d]pyrimidin-7-yl)-4-methoxypyridinium chloride 
• 1276005-49-2 [Fe(2:3,7:8,12:13,17:18-tetrabenzo-5,10,15,20-tetrakis(4-nonylphenyl)porphyrinate)(4-methoxypyridine)2]Cl 
• 1276005-63-0 [Fe(2:3,7:8,12:13,17:18-tetrabutano-5,10,15,20-tetrakis(4-nonylphenyl)porphyrinate)(4-methoxypyridine)2]Cl 
• 414910-14-8 (2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4-oxo-1-piperidinecarboxamide 
• 578711-12-3 C₂₇H₃₂F₇N₃O₂ 
• 578711-14-5 C₂₇H₃₂F₇N₃O₂ 
• 578711-32-7 C₂₈H₃₂F₇N₃O 
• 578711-34-9 C₂₈H₃₂F₇N₃O 
• 578711-36-1 C₂₇H₃₀F₇N₃O 
• 578711-38-3 C₂₇H₃₀F₇N₃O 
• 578711-16-7 C₂₅H₂₈F₇N₃O 

Relevant articles and documents

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Aromatic nitration with electrophilic N-nitropyridinium cations. Transitory charge-transfer complexes as key intermediates

Electrophilic aromatic nitration of various arenes (ArH) is shown to be critically dependent on labile charge-transfer complexes derived from N-nitropyridinium cations. The electrophiles XPyNO2+, with X = CN, CO2CH3, Cl, H, CH3, and OCH3, form a highly graded series of electron acceptors that produce divers [ArH,XPyNO2+] complexes, with charge-transfer excitation energies (hvCT) spanning a range of almost 50 kcal mol-1. The latter underlie an equally broad spectrum of aromatic substrate selectivities from the different nitrating agents (XPyNO2+), but they all yield an isomeric product distribution from toluene that is singularly insensitive to the X substituent. The strong correlation of the nitration rates with the HOMO-LUMO gap in the [ArH,XPyNO2+] complex is presented (Scheme III) in the context of a stepwise process in which the charge-transfer activation process is cleanly decoupled from the product-determining step-as earlier defined by Olah's requirement of several discrete intermediates. This charge-transfer formulation thus provides a readily visualized as well as a unifying mechanistic basis for the striking comparison of XPyNO2+ with other nitrating agents, including the coordinatively unsaturated nitronium cation (NO2+BF4-), despite their highly differentiated reactivities.

Photocatalytic deoxygenation of N-O bonds with rhenium complexes: From the reduction of nitrous oxide to pyridineN-oxides

The accumulation of nitrogen oxides in the environment calls for new pathways to interconvert the various oxidation states of nitrogen, and especially their reduction. However, the large spectrum of reduction potentials covered by nitrogen oxides makes it difficult to find general systems capable of efficiently reducing variousN-oxides. Here, photocatalysis unlocks high energy species able both to circumvent the inherent low reactivity of the greenhouse gas and oxidant N2O (E0(N2O/N2) = +1.77 Vvs.SHE), and to reduce pyridineN-oxides (E1/2(pyridineN-oxide/pyridine) = ?1.04 Vvs.SHE). The rhenium complex [Re(4,4′-tBu-bpy)(CO)3Cl] proved to be efficient in performing both reactions under ambient conditions, enabling the deoxygenation of N2O as well as synthetically relevant and functionalized pyridineN-oxides.

Copper-Catalyzed Methoxylation of Aryl Bromides with 9-BBN-OMe

A Cu-catalyzed cross-coupling reaction between aryl bromides and 9-BBN-OMe to provide aryl methyl ethers under mild conditions is reported. The oxalamide ligand BHMPO plays a key role in the transformation. Various functional groups on bromobenzenes are well tolerated, providing the desired anisole products in moderate to high yields.

Lewis Acidic Boranes, Lewis Bases, and Equilibrium Constants: A Reliable Scaffold for a Quantitative Lewis Acidity/Basicity Scale

A quantitative Lewis acidity/basicity scale toward boron-centered Lewis acids has been developed based on a set of 90 experimental equilibrium constants for the reactions of triarylboranes with various O-, N-, S-, and P-centered Lewis bases in dichloromethane at 20 °C. Analysis with the linear free energy relationship log KB=LAB+LBB allows equilibrium constants, KB, to be calculated for any type of borane/Lewis base combination through the sum of two descriptors, one for Lewis acidity (LAB) and one for Lewis basicity (LBB). The resulting Lewis acidity/basicity scale is independent of fixed reference acids/bases and valid for various types of trivalent boron-centered Lewis acids. It is demonstrated that the newly developed Lewis acidity/basicity scale is easily extendable through linear relationships with quantum-chemically calculated or common physical–organic descriptors and known thermodynamic data (ΔH (Formula presented.)). Furthermore, this experimental platform can be utilized for the rational development of borane-catalyzed reactions.