123296-53-7

Usage

InChI:InChI=1/C11H8N2O4/c14-10-8-5-7(13(16)17)4-6-2-1-3-12(9(6)8)11(10)15/h4-5H,1-3H2

Upstream product

• 79-37-8 oxalyl dichloride 
• 14026-45-0 6-nitro-1,2,3,4-tetrahydroquinoline 
• 4290-72-6 5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1,2-dione 

Downstream Products

• 123296-82-2 6-nitro-1,2,3,4-tetrahydroquinoline-8-carboxylic acid 

Relevant academic research and scientific papers

Synthesis and antirheumatic activity of novel tetrahydroquinoline-8-carboxylic acid derivatives

A study of the modification of N-alkylanthranilic acids to develop novel DMARDs is detailed. 1,2,3,4-Tetrahydroquinoline-8-carboxylic acid derivatives were found to exhibit a therapeutic effect on adjuvant arthritis and a suppressive effect on bone destruction.

Therapeutic agents of metabolic bone disease

New use of cyclic anthranilic acid derivatives of the following formula, STR1 wherein R1, R2 and R3 each independently indicate a hydrogen atom, chlorine atom, lower alkyl group having 1 to 3 carbon atoms, lower alkoxy group having 1 to 3 carbon atoms, amino group, nitro group, hydroxy group, sulfonamide group, trifluoromethyl group, cyano group, carboxyl group, carbamoyl group, acetyl group, benzoymethyl group which may be substituted, methylthio group, phenylethnyl group which may be substituted, alkanoylamino group having 1 to 3 carbon atoms, benzoylamino group which may be substituted, alkylsulfonylamino group having 1 to 3 carbon atoms or phenylsulfonylamino group which may be substituted; R4 and R5 each independently indicate a hydrogen atom, lower alkyl group having 1 to 3 carbon atoms, cyano group, carboxyl group, hydroxymethyl group, phenyl group which may be substituted or benzoyl group, R6 indicates a hydrogen atom, lower alkyl group having 1 to 3 carbon atoms or benzyl group; X indicates a methylene group, oxygen atom, sulfur atom, sulfinyl group or sulfonyl group, their acid or alkali salts thereof as therapeutic agents for metabolic bone diseases is described.

Cyclic anthranilic acid derivatives and process for their preparation

An antirheumatoid pharmaceutical composition containing a cyclic anthranilic acid derivative of the following formula, STR1 wherein R1, R2 and R3 each independently indicate a hydrogen atom, lower alkyl group having 1 to 3