123463-27-4

Upstream product

• 100-52-7 benzaldehyde 
• 139527-25-6 bis(4-chlorobutyl)zinc 
• 123463-25-2 (S)-1-{[((S)-5-Chloro-1-phenyl-pentyl)-dimethyl-silanyl]-methyl}-2-methoxymethyl-pyrrolidine 
• 5356-99-0 benzyl chloromethyl dimethyl silane 
• 123463-20-7 [(S)-2-(methoxymethyl)pyrrolidinomethyl]dimethyl benzylsilane 
• 927-73-1 3-butenyl chloride 
• 6280-87-1 δ-chlorovaleronitrile 
• 942-93-8 5-Chloro-1-phenyl-1-pentanone 

Downstream Products

• 123537-30-4 (S)-2-phenyltetrahydro-2H-pyran 

Relevant academic research and scientific papers

Evaluation of bifunctional chiral phosphine oxide catalysts for the asymmetric hydrosilylation of ketimines

A series of bifunctional phosphine oxides have been prepared and evaluated as catalysts for the trichlorosilane mediated asymmetric hydrosilylation of ketimines. bis-Phosphine oxides, hydroxy-phosphine oxides, and biaryl phosphine oxides all demonstrated good catalytic activity, but poor to moderate enantioselectivity. A bis-P-chiral phosphine oxide displayed the highest enantioselectivity of 60%.

Preparation of Functionalized Dialkylzinc Reagents via an Iodine-Zinc Exchange Reaction. Highly Enantioselective Synthesis of Functionalized Secondary Alcohols

Functionalized dialkylzincs are obtained by the reaction of polyfunctional alkyl iodides with Et2Zn in excellent yield.Their treatment with aldehydes, in the presence of the titanium catalyst 6, affords functionalized secondary alcohols with high enantios