1234862-80-6

Basic information

• Product Name: (3E)-4-(4-methoxyphenyl)-1-phenylbut-3-en-1-one
• Synonyms: (3E)-4-(4-methoxyphenyl)-1-phenylbut-3-en-1-one
• CAS NO: 1234862-80-6
• Molecular Weight: 252.313
• Mol File: 1234862-80-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (3E)-4-(4-methoxyphenyl)-1-phenylbut-3-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3E)-4-(4-methoxyphenyl)-1-phenylbut-3-en-1-one(1234862-80-6)
• EPA Substance Registry System: (3E)-4-(4-methoxyphenyl)-1-phenylbut-3-en-1-one(1234862-80-6)

Safety Data

• Hazardous Substances Data: 1234862-80-6(Hazardous Substances Data)

Upstream product

• 959-33-1 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one 
• 42205-96-9 (2-(4-methoxyphenyl)cyclopropyl)(phenyl)methanone 
• 23517-07-9 ((E)-1-(but-1-en-3-yn-1-yl)-4-methoxybenzene) 
• 591-50-4 iodobenzene 
• 1620635-61-1 1-((E)-4,4-dibromobuta-1,3-dienyl)-4-methoxybenzene 
• 24680-50-0 4-methoxy-trans-cinnamaldehyde 
• 41790-90-3 (E)-1-methoxy-4-(4-phenylbut-1-en-3-yn-1-yl)benzene 
• 98-86-2 acetophenone 
• 768-60-5 4-methoxyphenylacetylen 

Downstream Products

• 144774-54-9 (Z)-1-(4-methoxyphenyl)-4-phenylbut-2-ene-1,4-dione 
• 94540-81-5 2-(4-methoxyphenyl)-5-phenylfuran 

Relevant articles and documents

Regio- and Stereoselective Cascade of β,γ-Unsaturated Ketones by Dipeptided Phosphonium Salt Catalysis: Stereospecific Construction of Dihydrofuro-Fused [2,3-b] Skeletons

Chiral (dihydro)furo-fused heterocycles are significant structural motifs in numerous natural products, functional materials and pharmaceuticals. Therefore, developing efficient methods for preparing compounds with these privileged scaffolds is an important endeavor in synthetic chemistry. Herein, we develop an effective, modular method by a dipeptide-phosphonium salt-catalyzed regio- and stereoselective cascade reaction of readily available linear β,γ-unsaturated ketones with aromatic alkenes, affording a wide variety of structurally fused heterocyclic molecules in high yields with excellent stereoselectivities. Moreover, mechanistic investigations revealed that the bifunctional phosphonium salt controlled the regio- and stereoselectivities of this cascade reaction, particularly proceeding through the initial ketone α-addition followed by O-participated substitution; and the multiple hydrogen-bonding interactions between Br?nsted acid moieties of catalyst and nitro group of aromatic alkene were crucial in asymmetric induction. Given the generality, versatility, and high efficiency of this method, we anticipate that it will have broad synthetic utilities.

Visible-Light Induced Direct Synthesis of Polysubstituted Furans from Cyclopropyl Ketones

In this article, a photoredox protocol for the synthesis of furans via oxidative coupling of olefin generated in situ from cyclopropyl ketones with ketonic oxygen atom is presented. Moreover, bromination of furans in the presence of overstoichiometric oxidant has been achieved with high regioselectivity.

ZnII- and AuI-catalyzed regioselective hydrative oxidations of 3-En-1-ynes with selectfluor: Realization of 1,4-dioxo and 1,4-oxohydroxy functionalizations

Catalytic 1,4-dioxo functionalizations of 3-en-1-ynes to (Z)- and (E)-2-en-1,4-dicarbonyl compounds are described. This regioselective difunctionalization was achieved in one-pot operation through initial alkyne hydration followed by in situ Selectfluor oxidation. The presence of pyridine alters the reaction chemoselectivity to give 4-hydroxy-2-en-1-carbonyl products instead. A cooperative action of pyridine and ZnII assists the hydrolysis of key oxonium intermediate.