123631-83-4

Basic information

• Product Name: 4-Hydroxy-2,3-dimethoxypyridine
• Synonyms: 4-Hydroxy-2,3-dimethoxypyridine;2,3-Dimethoxy-pyridin-4-ol;4-Pyridinol, 2,3-dimethoxy-;4-Hydroxy-2,3-Dimethoxypyridine(WX649117)
• CAS NO: 123631-83-4
• Molecular Formula: C7H9NO3
• Molecular Weight: 155.15
• Mol File: 123631-83-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 358.4±37.0 °C(Predicted)
• Appearance: /
• Density: 1.201±0.06 g/cm3(Predicted)
• PKA: 4.89±0.23(Predicted)
• CAS DataBase Reference: 4-Hydroxy-2,3-dimethoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-2,3-dimethoxypyridine(123631-83-4)
• EPA Substance Registry System: 4-Hydroxy-2,3-dimethoxypyridine(123631-83-4)

Safety Data

• Hazardous Substances Data: 123631-83-4(Hazardous Substances Data)

Usage

General Description

4-Hydroxy-2,3-dimethoxypyridine is a chemical compound that belongs to the class of pyridine derivatives. It is a derivative of pyridine containing hydroxy and methoxy substituents at the 4 and 2,3 positions, respectively. This chemical compound has potential biological activities and is commonly used in the synthesis of pharmaceuticals and agrochemicals. Its unique structure and properties make it useful for various applications in the field of medicinal and agricultural chemistry. Additionally, it has been studied for its antioxidant and anti-inflammatory properties, making it a potential candidate for drug development in the future.

Upstream product

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Relevant articles and documents

Synthesis and Antineoplastic Evaluation of Mitochondrial Complex II (Succinate Dehydrogenase) Inhibitors Derived from Atpenin A5

Mitochondrial complex II (CII) is an emerging target for numerous human diseases. Sixteen analogues of the CII inhibitor natural product atpenin A5 were prepared to evaluate the structure–activity relationship of the C5 pyridine side chain. The side chain ketone moiety was determined to be pharmacophoric, engendering a bioactive conformation. One analogue, 1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)hexan-1-one (16 c), was found to have a CII IC50 value of 64 nm, to retain selectivity for CII over mitochondrial complex I (>156-fold), and to possess a ligand-lipophilicity efficiency (LLE) of 5.62, desirable metrics for a lead compound. This derivative and other highly potent CII inhibitors show potent and selective anti-proliferative activity in multiple human prostate cancer cell lines under both normoxia and hypoxia, acting to inhibit mitochondrial electron transport.

METHOD OF TREATING CANCER WITH ATPENIN A5 DERVIATIVES

The present invention includes molecules, composition, and methods for making and using a molecule having the formula (I), wherein R' is selected from H, methoxy, or methoxymethyl; X is selected from H, OH, methoxy, or methoxymethyl or O- methoxymethyl; Y is O; and R" is selected from H, OH, 2-furan, ethyl, propyl, pentyl, hexyl, heptyl, octyl, nonly, decyl, or dodecyl, that are saturated or unsaturated.

Titanium(II)-mediated cyclizations of (silyloxy)enynes: A total synthesis of (-)-7-demethylpiericidin A1

A concise total synthesis of 7-demethylpiericidin A1 has been completed. The synthesis features a titanium(II)-mediated cyclization of a (silyloxy)enyne as the key step and proceeds in nine steps from tiglic aldehyde. Copyright