123716-01-8

Upstream product

• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 86882-01-1 4-Methyl-2-(2-p-tolyl-2,3-dihydro-benzo[b][1,4]thiazepin-4-yl)-phenol 
• 86882-33-9 2-(1,1-Dioxo-2-p-tolyl-2,3-dihydro-1H-1λ⁶-benzo[b][1,4]thiazepin-4-yl)-4-methyl-phenol 
• 123743-13-5 6,4'-dimethylflavanone 
• 1391069-12-7 3-(4-phenylbenzofuro[3,2-b]pyridin-2-yl)coumarin 
• 1391068-93-1 C₁₇H₁₄O₂ 
• 1391069-06-9 3-(4-phenylbenzofuro[3,2-b]pyridin-2-yl)coumarin 
• 1413849-98-5 C₁₇H₁₈O₂ 
• 1413850-49-3 C₁₇H₁₆O 
• 78396-37-9 4',6-Dimethyl-3-hydroxyflavone 

Relevant academic research and scientific papers

Studies on ruthenium(III) chalconate complexes containing PPh 3/AsPh3

The reactions of [RuX3(EPh3)3] (X = Cl or Br; E = P or As) with 2′-hydroxychalcones in benzene under reflux led to the formation of [RuX2(EPh3)2(L)] (X = Cl or Br; E = P or As; L = chalcona

Iodine-mediated direct synthesis of 3-iodoflavones

Molecular iodine has been used for the regioselective, one pot, direct synthesis of 3-iodoflavones from 2′-allyloxy chalcones, 2′-hydroxy chalcones and flavones. Allyl deprotection, cyclization dehydrogenation and α-iodination of 2′-allyloxychalcones has been achieved in a single step to offer 3-iodoflavones.

Absorption and fluorescent studies of 3-hydroxychromones

The synthesis and spectral studies of variously substituted 3-hydroxychromones have been carried out. A key relationship between the structural motif of synthesized 3-hydroxychromones (3-HCs) and their fluorescent properties was found. The chromones substituted with electron-donating group at 4′-position expressed the red shift of the N and T band and also exhibited the increased fluorescent intensity ratio while the chromones with electron-withdrawing group showed the blue shift of the N and T band. Therefore, these 3-HCs may behave as the possible fluorescent probes.

An unexpected rearrangement-hydration reaction sequence of 2H-chromenes to dihydrochalcones under catalysis of HAuCl4

2-Aryl-2H-chromenes in aqueous DCM medium under catalysis of HAuCl 4 are converted into 3-(2-hydroxyaryl)-1-arylpropan-1-ones through hydration-rearrangement reaction sequence in very good yield. The key step probably involves the [1,5] hydride shift followed by the hydrolysis under the reaction condition. The notable advantages of this method are operational simplicity and ease of isolation of products and also provide a pathway to convert the chalcone into DHCs with the transposition of carbonyl group. 2012 Elsevier Ltd. All rights reserved.

Synthesis of flavanones by use of anhydrous potassium carbonate as an inexpensive, safe, and efficient basic catalyst

Anhydrous potassium carbonate has been utilized as an inexpensive, safe, and efficient basic catalyst for the synthesis of flavanones starting either from 2′-hydroxychalcones or from 2′-hydroxyacetophenones. In both the cases the favored reaction condition was either refluxing in a solvent with added catalyst or microwave irradiation on the catalyst.

Vicinal C,H Spin Coupling Constants in Determining the Stereochemistry of α-Substituted αβ-Unsaturated Ketones

The fully proton coupled ketone signal in the 13C n.m.r. spectra of eleven chalcones of known stereochemistry reveals diagnostic 3J-CO,H cis- and trans-coupling, which is used to determine the geometry of a benzylidine derivative of a dioxodibenzazocine.