123743-13-5

Upstream product

• 123743-09-9 6-Methyl-2-p-tolyl-chroman-4-one oxime 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 104-87-0 4-methyl-benzaldehyde 
• 123716-01-8 4,5'-Dimethyl-2'-hydroxy-chalkon 
• 38445-23-7 6-methyl-chromen-4-one 
• 5720-05-8 4-methylphenylboronic acid 

Downstream Products

• 88952-74-3 6-methyl-2-(p-tolyl)-4H-chromen-4-one 

Relevant academic research and scientific papers

An efficient and facile synthesis of flavanones catalyzed by N-methylimidazole

The use of N-methylimidazole as an efficient catalyst for the cyclization of 2'-hydroxychalcones to the corresponding flavanones in DMSO was investigated. The scope of this process was studied and various flavanones were obtained exclusively in good yields. Copyright

Rhodium/chiral diene-catalyzed asymmetric 1,4-addition of arylboronic acids to chromones: A highly enantioselective pathway for accessing chiral flavanones

Chromone has been noted to be one of the most challenging substrates in the asymmetric 1,4-addi-tion of α,β-unsaturated carbonyl compounds. By employing the rhodium complex associated with a chiral diene ligand, (R,R)-Ph-bod, the 1,4-addition of a variety of aryl-boronic acids was realized to give high yields of the corresponding flavanones with excellent enantioselectivities (≥97% ee, 99% ee for most substrates). Ring-opening side products, which would lead to erosion of product enantioselectivity, were not observed under the stated reaction conditions.

Synthesis of flavanones by use of anhydrous potassium carbonate as an inexpensive, safe, and efficient basic catalyst

Anhydrous potassium carbonate has been utilized as an inexpensive, safe, and efficient basic catalyst for the synthesis of flavanones starting either from 2′-hydroxychalcones or from 2′-hydroxyacetophenones. In both the cases the favored reaction condition was either refluxing in a solvent with added catalyst or microwave irradiation on the catalyst.

Oxidative Cleavage of 4-Oximinoflavans Using Iodobenzene Diacetate

Oxidation of 4-oximinoflavans (Ia-g) using iodobenzene diacetate leads to cleavage with the formation of corresponding flavanones (IIa-g) under neutral conditions in 60-80percent yields.