1237261-65-2

Basic information

• Product Name: (1S,2R)-2-((1,3-dioxoisoindolin-2-yl)Methyl)-N,N-diethyl-1-phenylcyclopropanecarboxaMide
• Synonyms: (1S,2R)-2-((1,3-dioxoisoindolin-2-yl)Methyl)-N,N-diethyl-1-phenylcyclopropanecarboxaMide;(1S,2R)-2-((1,3-dioxoisoindolin-2-yl)methyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide-cyclopropanecarboxamide
• CAS NO: 1237261-65-2
• Molecular Formula: C₂₃H₂₄N₂O₃
• Molecular Weight: 376.44826
• Mol File: 1237261-65-2.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1S,2R)-2-((1,3-dioxoisoindolin-2-yl)Methyl)-N,N-diethyl-1-phenylcyclopropanecarboxaMide(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2R)-2-((1,3-dioxoisoindolin-2-yl)Methyl)-N,N-diethyl-1-phenylcyclopropanecarboxaMide(1237261-65-2)
• EPA Substance Registry System: (1S,2R)-2-((1,3-dioxoisoindolin-2-yl)Methyl)-N,N-diethyl-1-phenylcyclopropanecarboxaMide(1237261-65-2)

Safety Data

• Hazardous Substances Data: 1237261-65-2(Hazardous Substances Data)

Usage

General Description

(1S,2R)-2-((1,3-dioxoisoindolin-2-yl)Methyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide is a chemical compound with a cyclopropane ring and a phenyl group. It also contains a diethyl substituent and a carboxamide functional group. The compound features an isoindolin-1,3-dione moiety, which is known for its biological activity and is often found in pharmaceuticals. This chemical compound may have potential applications in medicinal chemistry and pharmaceutical research due to its unique structural features.

Upstream product

• 140-29-4 phenylacetonitrile 
• 74-96-4 ethyl bromide 
• 923037-67-6 C₂₂H₂₇NO₄S 
• 1074-82-4 potassium phtalimide 
• 136918-14-4 phthalimide 
• 172015-99-5 (1 S,2 R)-N,N-diethyl-2-(hydroxymethyl)-1-phenylcyclopropane-carboxamide 
• 22613-99-6 cis-2-Hydroxymethyl-1-phenyl-cyclopropan-1-carbonsaeure 
• 63106-93-4 (1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one 
• 1237261-60-7 (1S,2R)-2-(chloromethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide 

Downstream Products

• 96847-54-0 (1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide 
• 101152-94-7 (1S,2R)-milnacipran hydrochloride 

Relevant articles and documents

Preparation method of levomilnacipran key intermediate

Levomilnacipran has a chemical name of (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide, is a medicine which is researched and developed by a French PierreFabre laboratory at the earliest time and is used for treating adult severe depre

Chiral Bidentate Boryl Ligand Enabled Iridium-Catalyzed Enantioselective C(sp3)-H Borylation of Cyclopropanes

We herein report an Ir-catalyzed enantioselective C(sp3)-H borylation of cyclopropanecarboxamides using a chiral bidentate boryl ligand for the first time. A variety of substrates with α-quaternary carbon centers could be compatible in this reaction to provide β-borylated products with good to excellent enantioselectivities. We have also demonstrated that the borylated products can be used as versatile precursors engaging in stereospecific transformations of C-B bonds, including the synthesis of a bioactive compound Levomilnacipran.

Preparation method of levomilnacipran hydrochloride

The invention provides a preparation method of levomilnacipran hydrochloride. According to the preparation method, a mixed liquid is obtained through a mixed reaction of a compound adopting the structure shown in the formula (II) and alkali; then acid is