123975-50-8

Upstream product

• 99793-10-9 N-benzyloxycarbonyl-L-asparatic acid β-allyl ester 
• 115-11-7 isobutene 
• 56-84-8 L-Aspartic acid 
• 501-53-1 benzyl chloroformate 
• 107-18-6 allyl alcohol 
• 123975-49-5 (S)-4-(allyloxy)-2-amino-4-oxobutanoic acid hydrochloride 
• 127949-84-2 (S)-2-Amino-succinic acid 1-tert-butyl ester; compound with trifluoro-acetic acid 
• 31139-36-3 dibenzyl dicarbonate 
• 34582-32-6 N-tert-butoxycarbonyl aspartic acid tert-butyl ester 
• 47307-26-6 (S)-2-benzyloxycarbonylamino-succinic acid 1-tert-butyl ester 
• 106-95-6 allyl bromide 

Downstream Products

• 144787-23-5 2-((S)-1-(benzyloxycarbonylamino)-2-tert-butoxy-2-oxoethyl)pent-4-enoic acid 
• 914648-29-6 C₂₀H₂₇NO₆ 
• 127605-39-4 2-oxo-3-(1-t-butyloxycarbonyl-1-benzyloxycarbonylamino-(S)-methyl)-4-ethyl-oxetane 
• 127605-42-9 t-butyl 2-benzyloxycarbonylamino-(S,Z)-3-hexenoate 
• 123975-64-4 t-butyl N(2-methoxy-2-phenyl-3,3,3-trifluoro-(R)-propionoyl)-2-amino-3-carbomethoxy-4-hydroxy-4-phenyl-(2S)-butanoate 
• 123975-51-9 t-butyl 2-benzyloxycarbonylamino-3-carbomethoxy-4-hydroxy-4-phenyl-(2S)-butanoate 
• 127605-38-3 t-butyl 2-amino-3-carbomethoxy-4-hydroxy-4-phenyl-(2S)-butanoate 
• 123999-77-9 t-butyl 2-benzyloxycarbonylamino-3-carbomethoxy-4-hydroxy-(2S)-hexanoate 
• 123975-61-1 t-butyl 2-benzyloxycarbonylamino-3-carboxy-4-hydroxy-(2S)-hexanoate 
• 60079-12-1 β-Methyl α-tert-butyl (2S)-N-(benzyloxycarbonyl)aspartate 
• 127605-40-7 (3E,2S)-2-benzyloxycarbonylamino-4-phenyl-3-butenoic acid tert-butyl ester 
• 127605-41-8 (3Z,2S)-2-benzyloxycarbonylamino-4-phenyl-3-butenoic acid tert-butyl ester 
• 123975-58-6 (2S)-2-benzyloxycarbonylamino-3-carboxy-4-hydroxy-4-phenyl-butanoic acid tert-butyl ester 
• 123975-57-5 t-butyl 2-benzyloxycarbonylamino-3-allyloxycarbonyl-4-hydroxy-(2S)-hexanoate 

Relevant academic research and scientific papers

NEW ENZYMATIC APPROACH TO THE SYNTHESIS OF CONVENIENT ASPARATIC ACID INTERMEDIATES IN PEPTIDE CHEMISTRY. SYNTHESIS OF N-BENZYLOXYCARBONYL-L-ASPARATIC ACID β-ALLYL ESTER.

Asparatic acid side chain protection by allyl ester functions has been facilitated by the direct synthesis of Z-Asp(OAll)-OH which can be performed by selective hydrolysis of Z-Asp(OAll)-OAll by means of papain catalysis.Both an optimization study and a batch synthesis are reported.Other synthesis routes are discussed.

ARGINASE INHIBITORS AND METHODS OF USE THEREOF

Disclosed are compounds of formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same, and methods of treating cancer or a respiratory inflammatory disease using the same: (I) wherein R11 is selec

Synthesis of tripeptide inhibitors of peptidylglycine α-amidating monooxygenase (PAM) containing D- and L-styrylglycine

Both enantiomers of (E)- and (Z)-2-amino-4-phenyl-3-butenoic acids (styrylglycines) 11a,b and 12a,b, were synthesised in non-racemic form, in 7 steps starting from either D- or L-aspartic acid. (E)-Styrylglycine 11a was converted to the tripeptide D-Phe-L-Phe-D-styrylglycine 15, and also to three diastereomeric tripeptides 16-18. All four tripeptides, and both enantiomers of N-acetylstyrylglycine 13a and 13b, were tested as inhibitors of peptidylglycine α-amidating monooxygenase (PAM).

Non-Proteinogenic Amino Acid Synthesis: Synthesis of β,γ-Unsaturated α-Amino Acids from Aspartic Acid

A general, stereospecific, synthesis of β,γ-unsaturated α-amino acids using the β-anion derived from aspartic acid is described.Keywords: aspartic acid; unsaturated acids

Asymmetric Amino Acid Synthesis: Preparation of the β Anion derived from Aspartic Acid

(S)-1-t-Butyl 4-methyl N-benzyloxycarbonylaspartate (5a), and (S)-1-t-butyl 4-allyl N-benzyloxycarbonylaspartate (5b) have been synthesized from (S)-aspartic acid (2), and can be readily alkylated and hydroxyalkylated at the β-carbon for asymmetric amino acid synthesis.