NEW ENZYMATIC APPROACH TO THE SYNTHESIS OF CONVENIENT ASPARATIC ACID INTERMEDIATES IN PEPTIDE CHEMISTRY. SYNTHESIS OF N-BENZYLOXYCARBONYL-L-ASPARATIC ACID β-ALLYL ESTER.

Article abstract of DOI:10.1016/S0040-4020(01)89204-8

Asparatic acid side chain protection by allyl ester functions has been facilitated by the direct synthesis of Z-Asp(OAll)-OH which can be performed by selective hydrolysis of Z-Asp(OAll)-OAll by means of papain catalysis.Both an optimization study and a batch synthesis are reported.Other synthesis routes are discussed.