123982-81-0Relevant articles and documents
Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl) ethyl)-acrylamide as a potent and efficacious KCNQ2 (Kv7.2) opener for the treatment of neuropathic pain
Wu, Yong-Jin,Conway, Charles M.,Sun, Li-Qiang,Machet, Frederic,Chen, Jie,Chen, Ping,He, Huan,Bourin, Clotilde,Calandra, Vincenzo,Polino, Joseph L.,Davis, Carl D.,Heman, Karen,Gribkoff, Valentin K.,Boissard, Christopher G.,Knox, Ronald J.,Thompson, Mark W.,Fitzpatrick, William,Weaver, David,Harden, David G.,Natale, Joanne,Dworetzky, Steven I.,Starrett Jr., John E.
, p. 6188 - 6191 (2013)
Acrylamide (S)-6, a potent and efficacious KCNQ2 (Kv7.2) opener, demonstrated significant activity in two models of neuropathic pain and in the formalin test, suggesting that KCNQ2 openers may be useful in the treatment of neuropathic pain including diabetic neuropathy.
Method for Preparing an Optically Active 1-(3-hydroxyphenyl)ethylamine
-
, (2017/06/20)
PURPOSE: A producing method of optically active 1-(3-hydroxyphenyl)ethylamine with the optical activity is provided to economically mass produce the 1-(3-hydroxyphenyl)ethylamine. CONSTITUTION: A producing method of optically active 1-(3-hydroxyphenyl)ethylamine comprises a step of reacting racemic 1-(3-hydroxyphenyl)ethylamine, with D-tartaric acid or L-tartaric acid to obtain semi tartarate, and a step of hydrolyzing the semi tartarate to form (S)- or (R)-1-(3-hydroxyphenyl)ethylamine.
Biocatalysts and methods for the synthesis of (S)-3-(1-aminoethyl)-phenol
-
Page/Page column, (2014/10/16)
The present disclosure provides engineered transaminase polypeptides having improved properties as compared to naturally occurring transaminases including the ability of converting the substrate, 3′-hydroxyacetophenone to (S)-3-(1-aminoethyl)-phenol in enantiomeric excess and high percentage conversion. Also provided are polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to synthesize (S)-3-(1-aminoethyl)-phenol and related compounds useful in the production of active pharmaceutical ingredients.