2454-35-5

Basic information

• Product Name: 3'-Acetoxyacetophenone
• Synonyms: M-ACETOXYACETOPHENONE;ACETIC ACID 3-ACETYL-PHENYL ESTER;3'-ACETOXYACETOPHENONE;3-ACETOXYACETOPHENONE;m-acetylphenyl acetate;3-Acetylphenyl acetate;1-(3-acetoxyphenyl)ethanone;Ethanone, 1-[3-(acetyloxy)phenyl]-
• CAS NO: 2454-35-5
• Molecular Formula: C₁₀H₁₀O₃
• Molecular Weight: 178.18
• EINECS: 219-524-8
• Product Categories: Aromatic Acetophenones & Derivatives (substituted)
• Mol File: 2454-35-5.mol
• Article Data: 17

Chemical Properties

• Melting Point: 46 °C
• Boiling Point: 147 °C / 9mmHg
• Flash Point: 126.5 °C
• Appearance: COA
• Density: 1.123 g/cm³
• Vapor Pressure: 0.00208mmHg at 25°C
• Refractive Index: 1.512
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• CAS DataBase Reference: 3'-Acetoxyacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-Acetoxyacetophenone(2454-35-5)
• EPA Substance Registry System: 3'-Acetoxyacetophenone(2454-35-5)

Safety Data

• Hazardous Substances Data: 2454-35-5(Hazardous Substances Data)

Usage

General Description

3'-Acetoxyacetophenone, also known as 1-(3-acetoxyphenyl)ethanone, is an organic compound that belongs to the class of aromatic ketones. It is a white solid with a melting point of 74-76°C and a boiling point of 275-276°C. This chemical is commonly used as a building block in the synthesis of various pharmaceuticals and organic compounds. It is also used as a flavoring agent in the food industry. The acetoxy group in the molecule provides reactivity for further chemical modifications, making it a versatile intermediate in organic synthesis. Additionally, 3'-Acetoxyacetophenone is used as a key component in the development of novel materials in the field of organic chemistry.

InChI:InChI=1/C10H10O3/c1-7(11)9-4-3-5-10(6-9)13-8(2)12/h3-6H,1-2H3

Upstream product

• 108-24-7 acetic anhydride 
• 118-93-4 o-hydroxyacetophenone 
• 121-71-1 3-Hydroxyacetophenone 
• 75-36-5 acetyl chloride 
• 10401-11-3 3-hydroxy phenylacetylene 
• 64-19-7 acetic acid 
• 108-46-3 recorcinol 
• 506-96-7 Acetyl bromide 
• 506-82-1 dimethylcadmium 
• 16446-73-4 3-(chlorocarbonyl)phenyl acetate 

Downstream Products

• 121-71-1 3-Hydroxyacetophenone 
• 38396-89-3 2-bromo-3-acetyloxylacetophenone 
• 1480644-35-6 N-(1-(3-chlorophenyl)-3-(3-acetoxyphenyl)-3-oxopropyl)-2-(4-nitrophenyl)acetamide 
• 61-76-7 phenylephrine hydrochloride 
• 2491-37-4 2-bromo-1-(3-hydroxyphenyl)ethanone 
• 1477503-62-0 3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-methylbenzenesulfonate 
• 1477503-61-9 3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenyl methanesulfonate 
• 1477503-60-8 1-(3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenoxy)propan-2-one 
• 1477503-58-4 3-(6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenyl 4-methylbenzenesulfonate 
• 1477503-57-3 3-(6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenyl methanesulfonate 
• 1314747-02-8 3-(8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-yl)phenol 
• 907961-67-5 C₁₄H₉F₃N₂O 
• 1477503-56-2 1-(3-(6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)phenoxy)propan-2-one 
• 1477503-80-2 3-(imidazo[1,2-a]pyrazin-2-yl)phenyl acetate 

Relevant articles and documents

Functionalized nanomagnetic graphene by ion liquid containing phosphomolybdic acid for facile and fast synthesis of paracetamol and aspirin

A nanocomposite has been synthesized by supporting of polyaniline-modified polyoxometalate-paired poly(ionic liquid) on the surface of magnetic graphene and characterized by various techniques. The fabricated nanocomposite was found to be a versatile catalyst for the synthesis of paracetamol and aspirin drugs showing high activity and selectivity. The observed high catalytic activity of the newly synthesized catalyst, in the preparation of these two important drugs, can be attributed to the presence of graphene, which provides high surface area for the supporting of polyaniline–polyoxometalate pair and also to the strong acidity of the solid acid. This catalytic system has several advantages, such as simple experimental process, easy separation of the product, solvent-free condition, efficient isolation, and recovery of the magnetic catalyst as well as high reusability.

Synthesis of Non-symmetrical Dispiro-1,2,4,5-Tetraoxanes and Dispiro-1,2,4-Trioxanes Catalyzed by Silica Sulfuric Acid

A novel protocol for the preparation of non-symmetrical 1,2,4,5-tetraoxanes and 1,2,4-trioxanes, promoted by the heterogeneous silica sulfuric acid (SSA) catalyst, is reported. Different ketones react under mild conditions with gem-dihydroperoxides or peroxysilyl alcohols/β-hydroperoxy alcohols to generate the corresponding endoperoxides in good yields. Our mechanistic proposal, assisted by molecular orbital calculations, at the ωB97XD/def2-TZVPP/PCM(DCM)//B3LYP/6-31G(d) level of theory, enhances the role of SSA in the cyclocondensation step. This novel procedure differs from previously reported methods by using readily available and inexpensive reagents, with recyclable properties, thereby establishing a valid alternative approach for the synthesis of new biologically active endoperoxides.

Efficient synthesis of (R)-phenylephrine using a polymer-supported Corey-Bakshi-Shibata catalyst

An efficient and mild synthetic route to (R)-phenylephrine hydrochloride using Corey-Bakshi-Shibata (CBS) catalyst was reported. In order to avoid a lengthy recovery process of the catalyst from homogeneous reaction, a polymer-supported CBS catalyst was prepared, and a preliminary attempt was made to achieve a continuous reduction on a laboratory scale, which contributes to synthesis of (R)-phenylephrine in a cost-effective way.