123994-79-6 Usage
General Description
2-(naphthalen-2-ylamino)-3,7-dihydro-6H-purin-6-one, also known as napabucasin, is a chemical compound with potential anticancer and anti-inflammatory properties. It inhibits the STAT3 signaling pathway, which is involved in regulating cell growth and survival, and has been studied for its potential in treating various types of cancer, including colorectal, pancreatic, and breast cancer. It has also been investigated for its anti-inflammatory effects and its potential to alleviate symptoms of inflammatory bowel disease. 2-(naphthalen-2-ylamino)-3,7-dihydro-6H-purin-6-one shows promise as a therapeutic agent for cancer and inflammatory conditions and is the subject of ongoing research and clinical trials.
Check Digit Verification of cas no
The CAS Registry Mumber 123994-79-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,9,9 and 4 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 123994-79:
(8*1)+(7*2)+(6*3)+(5*9)+(4*9)+(3*4)+(2*7)+(1*9)=156
156 % 10 = 6
So 123994-79-6 is a valid CAS Registry Number.
123994-79-6Relevant articles and documents
Structure-Activity Relationships of N2-Substituted Guanines as Inhibitors of HSV1 and HSV2 Thymidine Kinases
Hildebrand, Catherine,Sandoli, Daniele,Focher, Federico,Gambino, Joseph,Ciarrocchi, Giovanni,et al.
, p. 203 - 206 (2007/10/02)
A series of N2-phenylguanines was synthesized and tested for inhibition of the thymidine kinases encoded by Herpes simplex viruses type 1 and type 2.Compounds with hydrophobic, electron-attracting groups in the meta position of the phenyl ring