357-07-3

Basic information

• Product Name: OXYMORPHONE HCL NARCOTIC ANALGESIC
• Synonyms: OXYMORPHONE HCL NARCOTIC ANALGESIC;3,14-dihydroxy-4,5-alpha-epoxy-17-methyl-morphinan-6-onhydrochloride;4,5-alpha-epoxy-3,14-dihydroxy-17-methylmorphinan-6-onehydrochloride;morphinan-6-one,4,5-epoxy-3,14-dihydroxy-17-methyl-,hydrochloride,(5-alpha;numorphanhydrochloride;oxymorphinonehydrochloride;oxymorphone hydrochloride;(5alpha)-4,5-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one hydrochloride
• CAS NO: 357-07-3
• Molecular Formula: C₁₇H₁₉NO₄*ClH
• Molecular Weight: 338.80594
• EINECS: 206-610-5
• Mol File: 357-07-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 518.6°Cat760mmHg
• Flash Point: 267.5°C
• Appearance: /
• Density: 1.5g/cm³
• Vapor Pressure: 1.39E-11mmHg at 25°C
• Refractive Index: 1.709
• CAS DataBase Reference: OXYMORPHONE HCL NARCOTIC ANALGESIC(CAS DataBase Reference)
• NIST Chemistry Reference: OXYMORPHONE HCL NARCOTIC ANALGESIC(357-07-3)
• EPA Substance Registry System: OXYMORPHONE HCL NARCOTIC ANALGESIC(357-07-3)

Safety Data

• RIDADR: 3249
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 357-07-3(Hazardous Substances Data)

Usage

Uses

Analgesic (narcotic).

Brand name

Numorphan (Endo); Opana (Endo).

Clinical Use

Oxymorphone is a potent μ agonist (10 times greater than morphine) that is used to treat severe pain. It is used by intramuscular, subcutaneous, intravenous, and rectal routes of administration. The intramuscular dose of oxymorphone (1 mg) has a half-life of 3 to 4 hours. It is a Schedule II drug. Oxymorphone, because of its 14-hydroxy group, has low antitussive activity.

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx and HCl.

InChI:InChI=1/C17H19NO4/c1-18-7-6-16-13-9-2-3-10(19)14(13)22-15(16)11(20)4-5-17(16,21)12(18)8-9/h2-3,12,15,19,21H,4-8H2,1H3/t12-,15+,16+,17?/m1/s1

Upstream product

• 76-41-5 oxymorphone 
• 467-04-9 oripavine 
• 124-90-3 oxycodone hydrochloride 

Downstream Products

• 76-41-5 oxymorphone 

Relevant articles and documents

A method for synthesizing hydrochloric acid hydroxy morphinones

The invention discloses a synthesis method of oxymorphone hydrochloride. The synthesis method mainly comprises the following steps of: 1) alkalifying to obtain free alkali by taking oxycodone hydrochloride as an initial a raw material; 2) carrying out a demethylation reaction to obtain oxymorphone; 3) carrying out a hydrogenation reaction on the oxymorphone under acidic condition; and 4) salifying the hydrogenated product with hydrochloric acid to obtain the target product oxymorphone hydrochloride. The synthesis method disclosed by the invention has the advantages of available raw materials, high product purity and is easy to operate and is applicable to industrial production.

Forms of oxymorphone hydrochloride

The present disclosure is directed to crystalline forms of oxymorphone hydrochloride and compositions comprising any of the crystalline forms of oxymorphone hydrochloride. Also provided are processes for the preparation of crystalline forms of oxymorphone hydrochloride.

IMPROVED METHOD OF PREPARING OXYMORPHONE

The invention relates to an improved method of preparing oxymorphone or a salt thereof from oripavine. In particular, the invention relates to a method of preparing oxymorphone with a content of alpha-beta- unsaturated ketones (ABUK) 10 ppm.