124032-35-5

Upstream product

• 124032-36-6 (3S,5S)-5-[(1S)-1-(t-butoxycarbonyl)amino-2-cyclohexylethyl]-3-isopropyldihydrofuran-2(3H)-one 
• 109-73-9 N-butylamine 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 141258-90-4 (4S,5S)-5-((Z)-2-Butylcarbamoyl-3-methyl-but-1-enyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 20201-24-5 ethyl 3-methyl-2-oxobutanoate 
• 124032-42-4 [(S)-2-Cyclohexyl-1-((S)-4-isopropyl-5-oxo-2,5-dihydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester 
• 124032-43-5 [(S)-2-Cyclohexyl-1-((R)-4-isopropyl-5-oxo-2,5-dihydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester 
• 123580-22-3 [(S)-2-Cyclohexyl-1-((2S,4R)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester 
• 4522-04-7 ethyl N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-phenylalaninate 
• 124032-37-7 ((S)-3-tert-Butoxycarbonylamino-4-cyclohexyl-2-oxo-butyl)-phosphonic acid dimethyl ester 
• 169512-90-7 (S)-2-tert-Butoxycarbonylamino-3-cyclohexyl-propionic acid ethyl ester 
• 141258-89-1 (4S,5S)-4-Cyclohexylmethyl-5-((Z)-2-methoxycarbonyl-3-methyl-but-1-enyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 141258-95-9 (4S,5S)-4-Cyclohexylmethyl-5-((S)-2-methoxycarbonyl-3-methyl-butyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 138448-18-7 [R-(R*,S*)]-β-[[(1,1-Dimethylethoxy)carbonyl]-amino]-α-(2-furanyl)cyclohexanepropanol 

Downstream Products

• 105852-64-0 (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide 

Relevant academic research and scientific papers

PEPTIDES HAVING RENIN INHIBITORY ACTIVITY, THEIR PREPARATION AND USE

Compounds of formula (I): STR1 [in which: R 1 is heterocyclic group having 5 or 6 ring atoms, or--NR 7 R 8, where R 7 is alkyl and R 8 is optionally substituted phenyl, optionally substituted phenylalkyl or cycloalkyl; R 2 is optionally substituted phenyl

Synthesis of the hydroxyethylene dipeptide isostere, (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid n-butyl amide

A stereoselective synthesis of the hydroxyethylene dipeptide isostere, (2S,4S,5S)-5-amino-6-cyclohexyl-4-hydroxy-2-isopropyl hexanoic acid-n-butyl amide from Boc-L-phenylalanine is described.

THE SYNTHESIS OF (2S,4S,5S)-5-(N-BOC)-AMINO-6-CYCLOHEXYL-4-HYDORXY-2-ISOPROPYL-HEXANOIC ACID LACTONE, AN HYDROXYETHYLENE DIPEPTIDE ISOSTERE PRECURSOR

(2SR,4SR)-5-(S)-(N-Boc)-amino-cyclohexyl-4-hydroxy-2-isopropyl hexanoivc acid from (L)-phenylalanine and the preparation of the n-butyl amide of the 2(S),4(S),5(S) acid is presented.