124034-83-9

Upstream product

• 7429-44-9 2-methoxycyclohexanone 
• 626-55-1 3-Bromopyridine 
• 59983-39-0 (S)-1-amino-2-(methoxymethyl)pyrrolidine 
• 124034-66-8 2-(pyridin-3-yl)-cyclohexanone 
• 148322-26-3 (+)-2-methoxy-1-(pyrid-3-yl)cyclohexanol 

Downstream Products

• 133320-02-2 [1S,2R]-trans-2-Benzoyloxy-N-methyl-1-(pyrid-3-yl)cyclohexanecarbothioamide 
• 133219-30-4 [1R,2S]-trans-2-benzoyloxy-N-methyl-1-(pyrid-3-yl)cyclohexanecarbothioamide 
• 124097-89-8 (R)-2-Oxo-1-pyridin-3-yl-cyclohexanecarbothioic acid methylamide 
• 124097-84-3 [S]-(-)-N-methyl-2-oxo-1-(pyrid-3-yl)-cyclohexanecarbothioamide 
• 133321-22-9 (+/-)-trans-N-methyl-2-hydroxy-1-(3-pyridyl)cyclohexanecarbothioamide 
• 133321-21-8 [1S,2R]-trans-2-hydroxy-N-methyl-1-(pyridin-3-yl)cyclohexanecarbothioamide 
• 145931-39-1 C₂₇H₂₆N₂O₃S 
• 124034-18-0 (S)-2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-1-pyridin-3-yl-cyclohexanecarbothioic acid methylamide 

Relevant academic research and scientific papers

The synthesis of RP 66471. A potent potassium channel opener

The potent, homochiral, potassium channel opener, RP 66471, has been synthesised and shown to possess the (1R,2S) configuration.

Derivatives of thioformamide

Therapeutically useful thioformamide derivatives of the formula: STR1 wherein R represents alkyl, Het represents pyrid-3-yl, isoquinolin-4-yl, tetrahydroquinolin-3-yl, quinolin-3-yl, pyridazin-4-yl, pyrimid-5-yl, thiazol-5-yl, thieno[2,3-b]-pyridin-5-yl, pyrazin-2-yl, indol-3-yl and thieno[3,2-b]-pyridin-6-yl, Y represents ethylene, methylene or a valency bond, and X represents carbonyl, hydroxymethylene, >C=NOR1, >C=NN(R1)2 or >C=NN(R1)CON(R1)2 in which R1 represents hydrogen or optionally substituted alkyl, benzyl, phenethyl, 1-naphthylmethyl, 2-naphthylmethyl or pyrid-3-ylmethyl, or two R1 substituents on the same nitrogen atom may together form an optionally substituted alkylene radical chain and salts thereof, processes for their preparation and compositions containing them are described.

Thioformamide derivatives

Thioformamide derivatives of the formula: wherein R represents alkyl of 1 to 4 carbon atoms;, Het represents optionally substituted pyrid-3-yl, isoquinolin-4-yl, tetrahydroquinolin-3-yl, quinolin-3-yl, pyridazin-4-yl, pyrimid-5-yl, thiazol-5-yl, thieno[2,3--b]pyridin-5-yl, pyrazin-2-yl, indol-3-yl or thieno-[3,2--b]pyridin-6-yl;, and R1 represents a benzyl radical substituted on the ring by two to five fluorine atoms, and salts thereof are therapeutically useful.