133321-22-9

Upstream product

• 124097-89-8 (R)-2-Oxo-1-pyridin-3-yl-cyclohexanecarbothioic acid methylamide 
• 626-55-1 3-Bromopyridine 
• 7429-44-9 2-methoxycyclohexanone 
• 124034-07-7 (-)-N-methyl-2-oxo-1-(pyridin-3-yl)cyclohexanecarbothioamide 
• 124034-67-9 trans-1-[(pyridin-3-yl)bromomethyl] cyclopentanol 
• 124034-68-0 3-cyclopentylidenemethylpyridine 
• 124034-66-8 2-(pyridin-3-yl)-cyclohexanone 
• 500-22-1 3-pyridinecarboxaldehyde 
• 133667-53-5 (R)-2-[(E)-(S)-1-Phenyl-ethylimino]-1-pyridin-3-yl-cyclohexanecarbothioic acid methylamide 
• 145931-38-0 ((S)-1-Phenyl-ethyl)-[2-pyridin-3-yl-cyclohex-(E)-ylidene]-amine 
• 124034-18-0 (S)-2-[(E)-(S)-2-Methoxymethyl-pyrrolidin-1-ylimino]-1-pyridin-3-yl-cyclohexanecarbothioic acid methylamide 
• 124034-83-9 (2S)-2-methoxymethyl-1-[2-(pyridin-3-yl)-cyclohexylideneamino]pyrrolidine 
• 148322-26-3 (+)-2-methoxy-1-(pyrid-3-yl)cyclohexanol 

Downstream Products

• 134121-96-3 (1S,2R)-2-Methoxy-1-pyridin-3-yl-cyclohexanecarbothioic acid methylamide 
• 133219-30-4 Benzoic acid (1S,2R)-2-methylthiocarbamoyl-2-pyridin-3-yl-cyclohexyl ester 
• 133219-30-4 [1R,2S]-trans-2-benzoyloxy-N-methyl-1-(pyrid-3-yl)cyclohexanecarbothioamide 

Relevant academic research and scientific papers

Thioformamide derivatives

Thioformamide derivatives of the formula (I) STR1 wherein R represents an alkyl group; A represents either: (1) a phenyl group which is optionally substituted; or (2) heteroaromatic group (e.g. pyrid-3-yl, quinolin-3-yl); Y represents: an ethylene or methylene group or a direct bond; and B represents either: a) a phenyl, pyridyl, furyl or thienyl group, each of which may be optionally substituted, or b) a straight- or branched-chain alkyl, alkenyl, or cycloalkyl group, each of which may be optionally substituted. These compounds may be formulated into pharmaceutical preparations and have utility in the treatment of disorders associated with smooth muscle contraction.

The Synthesis of RP 65479. A Novel, Potent Potassium Channel Opener.

The potent potassium channel opener, 4, RP 65479, has been synthesized from the key intermediate, 2-(3-pyridyl)cyclohexanone, 8.

The synthesis of RP 66471. A potent potassium channel opener

The potent, homochiral, potassium channel opener, RP 66471, has been synthesised and shown to possess the (1R,2S) configuration.

Derivatives of thioformamide

Therapeutically useful thioformamide derivatives of the formula: STR1 wherein R represents alkyl, Het represents pyrid-3-yl, isoquinolin-4-yl, tetrahydroquinolin-3-yl, quinolin-3-yl, pyridazin-4-yl, pyrimid-5-yl, thiazol-5-yl, thieno[2,3-b]-pyridin-5-yl, pyrazin-2-yl, indol-3-yl and thieno[3,2-b]-pyridin-6-yl, Y represents ethylene, methylene or a valency bond, and X represents carbonyl, hydroxymethylene, >C=NOR1, >C=NN(R1)2 or >C=NN(R1)CON(R1)2 in which R1 represents hydrogen or optionally substituted alkyl, benzyl, phenethyl, 1-naphthylmethyl, 2-naphthylmethyl or pyrid-3-ylmethyl, or two R1 substituents on the same nitrogen atom may together form an optionally substituted alkylene radical chain and salts thereof, processes for their preparation and compositions containing them are described.