1240520-79-9

Upstream product

• 220416-57-9 2-((1S)-1-((1E)-1,2-dichloroethenyloxy)ethyl)-1,3,5-triisopropylbenzene 
• 860011-18-3 2-[(S)-1-((E)-1,2-Dichloro-vinyloxy)-ethyl]-1,3,5-triisopropyl-benzene 
• 111-34-2 -butyl vinyl ether 
• 102225-88-7 (-)-(S)-1-(2,4,6-triisopropylphenyl)ethanol 
• 108-05-4 vinyl acetate 

Downstream Products

• 1611460-75-3 methyl (3R,5S)-2-benzyl-3-(2-methoxy-2-oxoethyl)-5-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]isoxazolidine-3-carboxylate 
• 1611460-77-5 methyl (3R,5S)-2-benzhydryl-3-(2-methoxy-2-oxoethyl)-5-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]isoxazolidine-3-carboxylate 
• 1611460-84-4 methyl (3S,5R)-3-(2-methoxy-2-oxoethyl)-5-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]isoxazolidine-3-carboxylate 
• 1611460-89-9 methyl (3S,5R)-3-(2-methoxy-2-oxoethyl)-2-(2,2,2-trifluoroacetyl)-5-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]isoxazolidine-3-carboxylate 
• 1611460-90-2 1,2-dimethyl 3-[(S)-1-(2,4,6-triisopropylphenyl)ethyl] (R)-2-(2,2,2-trifluoroacetamido)propane-1,2,3-tricarboxylate 

Relevant academic research and scientific papers

Thermal [2 + 2]-Cycloaddition of Ketenes with Chiral Enol Ethers: Route to Densely Substituted Cyclobutanones

Access to chiral polysubstituted cyclobutanones by [2 + 2]-cycloaddition of ketenes with chiral acyclic enol ethers is reported. A wide variety of easily accessible di- and monosubstituted ketenes were found to react with a very high degree of stereoselec

Asymmetric access to α-substituted functional aspartic acid derivatives by a [3+2] strategy employing a chiral dienophile

Enantiopure vinyl ethers of Stericol underwent diastereoselective thermal 1,3 dipolar cycloadditions with N-benzyl, N-benzhydryl, and N-PMB aspartate ester nitrones. Chemoselective N-debenzylation of the resulting cycloadducts afforded diastereomerically and enantiomerically pure crystalline NH-isoxazolidine, the absolute configuration of which was established by X-ray crystallography. N-Protection and N-O cleavage of this isoxazolidine gave enantioenriched quaternary aspartate derivatives bearing functionalized side chains.