124156-34-9

Upstream product

• 3350-78-5 3,3-Dimethylacryloyl chloride 
• 124156-20-3 (4-methoxyphenyl-benzylidene)-carbamic acid methyl ester 
• 104-94-9 4-methoxy-aniline 
• 131533-51-2 3-Isopropyl-1-(4-methoxy-phenyl)-4-oxo-3-phenylsulfanyl-azetidine-2-carboxylic acid methyl ester 
• 124175-15-1 cis-1-p-anisyl-3-(1'-methylvinyl)-4-carbomethoxy-2-azetidinone 

Downstream Products

• 124156-26-9 cis-3-Isopropyl-4-(methoxycarbonyl)-1-(4-methoxyphenyl)azetidin-2-one 
• 131533-52-3 4-hydroxymethyl-3-(1-methylethylidene)azetidin-2-one 
• 123003-79-2 1-p-anisyl-3-isopropyl-4-acetoxy-2-azetidinone 
• 124156-28-1 cis-3-isopropyl-1-(4-methoxyphenyl)-4-oxoazetidine-2-carboxylic acid 
• 82290-87-7 3-isopropyl-4-acetoxy-2-azetidinone 
• 131533-55-6 [2-(2-Chloro-acetoxymethyl)-1-(4-methoxy-phenyl)-4-oxo-azetidin-(3E)-ylidene]-acetic acid methyl ester 
• 131533-53-4 Chloro-acetic acid 3-isopropylidene-1-(4-methoxy-phenyl)-4-oxo-azetidin-2-ylmethyl ester 
• 131533-54-5 Chloro-acetic acid 1-(4-methoxy-phenyl)-3,4-dioxo-azetidin-2-ylmethyl ester 

Relevant academic research and scientific papers

Addition of α-bromoesters to Azetidine-2,3-diones Promoted by Zinc-Trimethylchlorosilane: A General Synthesis of 3-trimethylsilyloxyazetidin-2-ones and α-Alkylidene β-lactams.

A convenient procedure for the preparation of α-alkylidene β-lactams from monocyclic azetidine-2,3-diones by means of the Reformatsky reaction is described.

β-Lactams via α,β-Unsaturated Acid Chlorides: Intermediates for Carbapenem Antibiotics

Stereocontrolled synthesis of α-vinyl β-lactams and their transformation to convenient intermediates for PS-5, PS-6, asparenomycin, and thienamycin are described.