82290-87-7

Upstream product

• 1189-71-5 isocyanate de chlorosulfonyle 
• 73660-79-4 3-methylbut-1-enyl acetate 
• 7757-83-7 sodium sulfite 
• 124156-26-9 cis-3-Isopropyl-4-(methoxycarbonyl)-1-(4-methoxyphenyl)azetidin-2-one 
• 124156-27-0 cis-1-p-anisyl-3-isopropyl-4-carbethoxy-2-azetidinone 
• 124156-35-0 1-p-anisyl-3-isopropylidene-4-carbethoxy-2-azetidinone 
• 124156-25-8 cis-1-p-Methoxyphenyl-3-isopropenyl-4-ethoxycarbonylazetidinone 
• 124156-28-1 cis-3-isopropyl-1-(4-methoxyphenyl)-4-oxoazetidine-2-carboxylic acid 
• 124175-15-1 cis-1-p-anisyl-3-(1'-methylvinyl)-4-carbomethoxy-2-azetidinone 
• 124156-34-9 1-p-anisyl-3-isopropylidene-4-carbomethoxy-2-azetidinone 
• 3350-78-5 3,3-Dimethylacryloyl chloride 
• 590-86-3 isovaleraldehyde 
• 123003-79-2 1-p-anisyl-3-isopropyl-4-acetoxy-2-azetidinone 

Relevant academic research and scientific papers

β-Lactams via α,β-Unsaturated Acid Chlorides: Intermediates for Carbapenem Antibiotics

Stereocontrolled synthesis of α-vinyl β-lactams and their transformation to convenient intermediates for PS-5, PS-6, asparenomycin, and thienamycin are described.

6-substituted penem compounds

The invention relates to 2-penem-3-carboxylic acid compounds of the formula STR1 in which Ra represents an organic radical bonded by a carbon atom to the ring carbon atom, a free, etherified or esterified hydroxy or mercapto group or a halogen atom, R1 represents hydrogen, an organic radical bonded by a carbon atom to the ring carbon atom, or an etherified mercapto group, and R2 represents a hydroxy group or an R2A radical that together with the carbonyl grouping --C(=O)-- forms a protected carboxyl group, and to salts of such compounds with salt-forming groups, processes for the manufacture of such compounds, pharmaceutical preparations containing compounds of the formula I with pharmacological properties, and their use. The compounds have antibiotic activity.

A Short and Stereoselective Synthesis of the Carbapenem Antibiotic PS-5

The benzyl ester (3) and p-nitrobenzyl ester (PNB ester) (4) of the antibiotic PS-5 and the bis-protected PS-6 (5) were stereoselectively synthesised by application of the new carbon-carbon bond formation reaction at the C-4-position of 4-acetoxy-3-ethyl-

FACILE SYNTHESIS OF CARBAPENEM ANTIBIOTICS. THE FIRST AND SIMPLE STEREOSELECTIVE SYNTHESIS OF ANTIBIOTIC PS-5 BENZYL ESTER

Antbiotic PS-5 benzyl ester was stereoselectively synthesized by using a new carbon-carbon bond formation reaction at the C4-position of azeticin-2-one, as a key reaction.