1242269-88-0

Upstream product

• 1360702-28-8 N-(3-amino-4-chlorobenzyl)pivalamide 
• 102368-13-8 1,1'-Thiocarbonyldi-2(1H)-pyridone 
• 100398-63-8 4-chloro-3-nitro-benzylamine 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 1380920-99-9 N-{4-chloro-3-[(2-amino-5-chloro-4-(3,3-difluoropyrrolidin-1-yl)phenyl)thioureido]-benzyl}-2,2-dimethyl-propionamide 
• 1380919-26-5 N-{4-chloro-3-[3-methyl-6-(4-trifluoromethyl-piperidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-2,2-dimethyl-propionamide 
• 1380921-23-2 N-(4-chloro-3-{3-[2-methylamino-5-(4-trifluoromethyl-piperidin-1-yl)-phenyl]-thioureido}-benzyl)-2,2-dimethyl-propionamide 
• 1380919-20-9 N-{4-chloro-3-[5-chloro-6-(2-dimethylcarbamoyl-pyrrolidin-1-yl)-1H-benzimidazol-2-ylamino]-benzyl}-2,2-dimethyl-propionamide 
• 1380919-16-3 N-{4-chloro-3-[6-chloro-5-(3,3-difluoropyrrolidin-1-yl)-1H-benzo[d]imidazol-2-ylamino]benzyl}-2,2-dimethyl-propionamide 
• 1360699-14-4 N-{4-chloro-3-[6-(4-bromo-phenylcarbamoyl)-5-(2,2-difluoro-ethoxy)-3-methyl-3H-imidazo[4,5-b]pyridin-2-ylamino]-benzyl}-2,2-dimethyl-propionamide 
• 1360702-29-9 N-(4-chloro-3-{N'-[3-(4-bromo-phenylcarbamoyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-pyridin-5-yl]-thioureido}-benzyl)-2,2-dimethyl-propionamide 

Relevant academic research and scientific papers

NOVEL COMPOUNDS

This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), to pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R3, R4, R6, R2, R7, R8, R9, Ra, Rb have meanings given in the description.

2-(ARYLAMINO)-3H-IMIDAZO[4,5-B]PYRIDINE-6-CARBOXAMIDE DERIVATIVES AND THEIR USE AS MPGES-1 INHIBITORS

This invention relates to compounds of formula (I) their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of

2 -AMINOBENZ IMIDAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF INFLAMMATION

This invention relates to compounds of formula (I), their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the 10 treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R3, R4, R6, R2,R7, R8, R9, Ra, Rb have meanings given in the description.

NEW COMPOUNDS

This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of i