13287-30-4

Basic information

• Product Name: 4-methylbenzene-1,2-diyl diacetate
• Synonyms: 1,2-Benzenediol, 4-methyl-, diacetate; 4-Methyl-1,2-benzenediol diacetate
• CAS NO: 13287-30-4
• Molecular Formula: C₁₁H₁₂O₄
• Molecular Weight: 208.2106
• Mol File: 13287-30-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 295.9°C at 760 mmHg
• Flash Point: 144.1°C
• Density: 1.15g/cm³
• Vapor Pressure: 0.00148mmHg at 25°C
• Refractive Index: 1.505
• CAS DataBase Reference: 4-methylbenzene-1,2-diyl diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methylbenzene-1,2-diyl diacetate(13287-30-4)
• EPA Substance Registry System: 4-methylbenzene-1,2-diyl diacetate(13287-30-4)

Safety Data

• Hazardous Substances Data: 13287-30-4(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 452-86-8 4-methyl-1,2-dihydroxybenzene 
• 2563-07-7 2-ethoxy-4-methylphenol 
• 75-36-5 acetyl chloride 
• 20794-09-6 4,5-Diacetoxy-2-methylbenzolsulfonylchlorid 
• 3131-54-2 4-methylbenzo-1,2-quinone 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 6921-64-8 4'-hydroxy-2'-methylacetophenone 
• 122-46-3 3-acetoxytoluene 
• 7244-03-3 6,6-diacetoxy-4-methyl-cyclohexa-2,4-dienone 

Downstream Products

• 124254-92-8 4-(bromomethyl)-1,2-phenylene diacetate 
• 77028-40-1 (+/-)-ethyl-(2'-hydroxy-3'-methoxy-5'-methylphenyl)butanoate 

Relevant articles and documents

Evaluating prodrug strategies for esterase-triggered release of alcohols

Prodrugs are effective tools in overcoming drawbacks typically associated with drug formulation and delivery. Those employing esterase-triggered functional groups are frequently utilized to mask polar carboxylic acids and phenols, increasing drug-like properties such as lipophilicity. Herein we detail a comprehensive assessment for strategies that effectively release hydroxy and phenolic moieties in the presence of an esterase. Matrix metalloproteinases (MMPs) serve as our proof-of-concept target. Three distinct ester-responsive protecting groups are incorporated into MMP proinhibitors containing hydroxy moieties. Analytical evaluation of the proinhibitors demonstrates that the use of a benzyl ether group appended to the esterase trigger leads to considerably faster kinetics of conversion and enhanced aqueous stability when compared with more conventional approaches where the trigger is directly attached to the inhibitor. Biological assays confirm that all protecting groups effectively cleave in the presence of esterase to generate the active inhibitor. The superior reaction-based prodrug strategies presented here should serve as a platform for esterase-responsive prodrug design in the future.

The Synthesis of Propellane Compounds from 2,3-Disubstituted Indoles and o-Benzoquinones

The reaction of 2,3-dihydro-1H-cyclopentindole 3 and 1,2,3,4-tetrahydrocarbazole 4 with substituted o-benzoquinones yielded - and propellanes, respectively.The physical and chemical properties of the propellane compounds were investigated