1242985-31-4Relevant articles and documents
Catalytic asymmetric synthesis of functionalized α,α- disubstituted α-amino acid derivatives from racemic unprotected α-amino acids via in-situ generated azlactones
Weber, Manuel,Frey, Wolfgang,Peters, Rene
supporting information; experimental part, p. 1443 - 1449 (2012/07/13)
Masked and activated highly enantioenriched α,α-disubstituted α-amino acids with an additional adjacent stereocenter were formed by a tandem reaction involving five steps using racemic unprotected amino acid substrates. Key step is the 1,4-addition of in-situ generated azlactones to a broad number of enones. The products of this step-economic route can, e.g., be useful for a divergent and rapid access to biologically interesting unnatural glutamic acid derivatives. Copyright
Bispalladacycle-catalyzed bronsted acid/base-promoted asymmetric tandem azlactone formation-michael addition
Weber, Manuel,Jautze, Sascha,Frey, Wolfgang,Peters, Rene
supporting information; experimental part, p. 12222 - 12225 (2010/11/03)
Cooperative activation by a soft bimetallic catalyst, a hard Bronsted acid, and a hard Bronsted base has allowed the formation of highly enantioenriched, diastereomerically pure masked α-amino acids with adjacent quaternary and tertiary stereocenters in a single reaction starting from racemic N-benzoylated amino acids. The products can, for example, be used to prepare bicyclic dipeptides.
