124341-05-5

Basic information

• Product Name: 2-Azidocarbonyl-3-nitro-benzoic acid ethyl ester
• Synonyms: 2-Azidocarbonyl-3-nitro-benzoic acid ethyl ester
• CAS NO: 124341-05-5
• Molecular Weight: 264.197
• Mol File: 124341-05-5.mol

Chemical Properties

• CAS DataBase Reference: 2-Azidocarbonyl-3-nitro-benzoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Azidocarbonyl-3-nitro-benzoic acid ethyl ester(124341-05-5)
• EPA Substance Registry System: 2-Azidocarbonyl-3-nitro-benzoic acid ethyl ester(124341-05-5)

Safety Data

• Hazardous Substances Data: 124341-05-5(Hazardous Substances Data)

Upstream product

• 136285-66-0 3-nitro-phthalic acid-1-ethyl ester-2-chloride 
• 603-11-2 3-nitrophthalic acid 
• 75-65-0 tert-butyl alcohol 
• 16533-45-2 ethyl 2-carboxy-3-nitrobenzoate 

Downstream Products

• 136285-65-9 ethyl 2-[(N-tert-butoxycarbonyl)amino]-3-nitrobenzoate 
• 603-81-6 2,3-diaminobenzoic acid 
• 124340-67-6 2-(4-Acetylamino-phenyl)-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide 
• 124340-75-6 2-(2,3-Dimethoxy-phenyl)-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide 
• 124340-66-5 2-Biphenyl-4-yl-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide 
• 124340-55-2 2-(2-Methoxy-phenyl)-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide 
• 124340-68-7 2-(4-Dimethylamino-phenyl)-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide 
• 124340-56-3 2-(2-Chloro-phenyl)-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide 
• 124340-63-2 2-(4-Methoxy-phenyl)-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide 
• 124340-59-6 N'-<2-(N,N-dimethylamino)ethyl>-2-(3'-methoxyphenyl)-1H-benzimidazole-4-carboxamide 
• 124340-54-1 2-o-Tolyl-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide 
• 124340-64-3 2-(4-Chloro-phenyl)-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide 
• 124340-60-9 2-(3-Chloro-phenyl)-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide 
• 124340-62-1 2-p-Tolyl-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide 

Relevant articles and documents

Synthesis Method for Candesartan Cilexetil Intermediate

A synthesis method for a candesartan cilexetil intermediate represented by formula (II) is provided. The method includes (1) dissolving a compound represented by formula (IV) to an aprotic solvent to obtain a first mixed solution, and dissolving a phase transfer catalyst and an azidation reagent to water to obtain a second mixed solution; (2) dropping the first mixed solution to the second mixed solution for azidation reaction, and after the reaction is ended, standing and layering same to obtain an organic phase containing a compound represented by formula (V); (3) dropping the obtained organic phase containing the compound represented by formula (V) to tertiary butyl alcohol for rearrangement reaction, and after the reaction is ended, concentrating same to obtain a solid or oily material, then adding a crystallizing solvent to the obtained solid or oily material for recrystallization, and separating same to obtain a crystal.

Potential Antitumor Agents. 59. Structure-Activity Relationships for 2-Phenylbenzimidazole-4-carboxamides, a New Class of "Minimal" DNA-Intercalating Agents Which May Not Act via Topoisomerase II

A series of substituted 2-phenylbenzimidazole-4-carboxamides has been synthesized and evaluated for in vitro and in vivo antitumor activity.These compounds represent the logical conclusion to our search for "minimal" DNA-intercalating agents with the lowest possible DNA-binding constants.Such "2-1" tricyclic chromophores, of lower aromaticity than the structurally similar 2-phenylquinolines, have the lowest DNA binding affinity yet seen in the broad series of tricyclic carboxamide intercalating agents.Despite very low in vitro cytotoxicities, several of the compoundshad moderate levels of in vivo antileukemic effects.However, the most interesting aspect of their biological activity was the lack of cross-resistance shown to an amsacrine-resistant P388 cell line, suggesting that these compounds may not express their cytotoxicity via interaction with topoisomerase II.