1243697-43-9Relevant academic research and scientific papers
Synthesis, cytotoxic activity, and thermal studies of novel N-[(1,3-diphenylpyrazol-4-yl)methyl] α-amino acids
Joksovic, Milan D.,Bogdanovic, Gordana,Kojic, Vesna,Szecsenyi, Katalin Meszaros,Leovac, Vukadin M.,Jakimov, Dimitar,Trifunovic, Snezana,Markovic, Violeta,Joksovic, Ljubinka
, p. 850 - 856 (2010)
(Chemical Equation Presented) New N-[(1,3-diphenylpyrazol-4-yl)methyl]a- amino acids (1a-i) have been synthesized and tested in vitro for their antiproliferative activity against human myelogenous leukemia K562, colon adenocarcinoma HT-29, cervix carcinoma HeLa, and normal fetal lung fibroblasts, MRC-5. Compounds derived from both phenylalanine enantiomer precursors appeared to be the most active against myelogenous leukemia K562 cell lines with a high cytotoxic potential.
