124469-06-3Relevant academic research and scientific papers
NEW CCR2 RECEPTOR ANTAGONISTS AND USES THEREOF
-
Page/Page column 50, (2012/01/14)
The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD.
Masked Lithium Bishomoenolates: Useful Intermediates in Organic Synthesis
Ramon, Diego J.,Yus, Miguel
, p. 3825 - 3831 (2007/10/02)
The lithiation of the chloro ketals 9 with lithium naphthalenide at -78 deg C led to the corresponding masked lithium bishomoenolates 4, which are stable species under these conditions and react with different electrophilic reagents (H2O, D2O, i-PrCOH, Ph
Stereoselective Syntheses of α-Substituted Cyclic Ethers and syn-1,3-Diols
Homma, Koichi,Takenoshita, Haruhiro,Mukaiyama, Teruaki
, p. 1898 - 1915 (2007/10/02)
In the presence of a catalytic amount of triphenylmethylium hexachloroantimonate or a catalyst system of antimony pentachloride, chlorotrimethylsilane and tin(II)iodide, α-substituted cyclic ethers are stereoselectively prepared from lactones by successiv
SUBSTITUTION REACTIONS OF 2-BENZENESULPHONYL CYCLIC ETHERS WITH CARBON NUCLEOPHILES
Brown, Dearg S.,Bruno, Maurizio,Davenport, Raymond J.,Ley, Steven V.
, p. 4293 - 4308 (2007/10/02)
Direct substitution of 2-benzenesulphonylcyclic ethers was studied using a variety of carbon nucleophiles.These nucleophiles included organozinc reagents (derived from aryl, vinyl and alkynyl Grignard reagents) or silyl enol ethers, silyl ketene acetals,
SUBSTITUTION REACTIONS OF 2-BENZENESULPHONYL CYCLIC ETHERS WITH SILYL ENOL ETHERS PROMOTED BY ALUMINIUM TRICHLORIDE
Brown, Dearg S.,Ley, Steven V.,Bruno, Maurizio
, p. 773 - 777 (2007/10/02)
Several cyclic ether 2-benzenesulphones were shown to react with silyl enol ethers in the presence of AlCl3 to give the corresponding alkylated products in good yield.Where substitution occured to give 2,6-disubstituted products there was a marked prefere
A CONVENIENT SYNTHESIS OF CYCLIC ETHERS FROM SILOXY CARBONYL COMPOUNDS
Homma, Koichi,Mukaiyama, Teruaki
, p. 259 - 262 (2007/10/02)
Five-seven membered cyclic ethers are prepared by one-pot procedure in good yields from γ-, δ-, and ε-siloxy carbonyl compounds, respectively, on treatment with silyl nucleophiles (triethylsilane, allyltrimethylsilane, trimethylsilyl cyanide, etc.) in the
