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Usage

Uses

Used in Pharmaceutical Industry:
(S)-1-benzyl-3-hydroxypiperidin-2-one is used as a key intermediate in the synthesis of various drug molecules, contributing to the development of new pharmaceuticals and biologically active compounds. Its unique structure allows for the creation of a wide range of organic compounds with potential therapeutic applications.
Used in Organic Synthesis:
(S)-1-benzyl-3-hydroxypiperidin-2-one serves as a valuable building block in organic synthesis, facilitating the production of a diverse array of chemical compounds for research and industrial applications. Its presence of functional groups makes it a suitable candidate for further chemical modifications and reactions.

Upstream product

• 111492-67-2 1-benzyl-3-benzyloxy-2-piperidone 
• 614754-21-1 3-acetoxy-1-benzyl-2-piperidinone 
• 89180-84-7 2,5-Dibromopentanoic Acid Bromide 
• 77868-86-1 3-bromo-1-benzyl-2-piperidinone 
• 77868-79-2 N-benzyl-2,5-dibromopentanamide 
• 100-46-9 benzylamine 
• 16867-04-2 dihydroxypyridine 
• 19365-08-3 3-hydroxypiperidin-2-one 
• 2905-56-8 N-Benzylpiperidine 
• 4783-65-7 N-benzyl-2-piperidinone 

Downstream Products

• 111492-76-3 1-Benzyl-3-[(3-trifluoromethyl-phenyl)-hydrazono]-piperidin-2-one 
• 111492-77-4 1-Benzyl-3-[(4-trifluoromethyl-phenyl)-hydrazono]-piperidin-2-one 
• 111492-73-0 1-Benzyl-3-[(3-methoxy-phenyl)-hydrazono]-piperidin-2-one 
• 111492-74-1 1-Benzyl-3-[(4-fluoro-phenyl)-hydrazono]-piperidin-2-one 
• 111492-78-5 1-benzyl-3-phenylhydrazono-2-piperidone 
• 111492-84-3 6-Fluoro-2,3,4,9-tetrahydro-2-(phenylmethyl)-1H-pyrido<3,4-b>indol-1-one 
• 111492-86-5 N_b-benzyl-1,2,3,4-tetrahydro-β-carbolin-1-one 

Relevant academic research and scientific papers

Electrochemical deamination of alkoxyamine lactams

An anodic electrochemical deamination of 3-alkoxyamine lactams to 3-hydroxy lactams was developed. The electrochemical transformation was achieved by using reticulated vitreous carbon (RVC) and stainless-steel electrodes in aqueous ethanolic solution of NaOAc. This simple electrochemical procedure represents an ecofriendly alternative to the traditional chemical reductive deamination, which requires of a large excess of Zn (up to 40 equivalents) and acetic acid.

Transition Metal-Free Selective Double sp3 C-H Oxidation of Cyclic Amines to 3-Alkoxyamine Lactams

The first chemical method for selective dual sp3 C-H functionalization at the alpha-and beta positions of cyclic amines to their corresponding 3-alkoxyamine lactams is reported. Unlike traditional Cα-H oxidation of amines to amides mediated by transition metals, the present protocol, which involves the use of NaClO2/TEMPO/NaClO in either aqueous or organic solvent, not only allows the Cα-H oxidation but also the subsequent functionalization of the unreactive β-methylene group in an unprecedented tandem fashion and using environmentally friendly reactants.

Chemoenzymatic enantioselective synthesis of 3-hydroxy-2-pyrrolidinones and 3-hydroxy-2-piperidinones

The enantioselective synthesis of 3-hydroxypyrrolidin-2-ones and 3-hydroxy piperidin-2-ones has been carried out in high enantiomeric excess employing immobilized lipase from Pseudomonas cepacia.

Synthesis and Serotonin-Receptor Activity of Substituted 1-Oxo-1,2,3,4-tetrahydro-&β-carbolines

2,3-Dihydroxypyridine is used as a starting material for the synthesis of donor and acceptor substituted 1-oxo-1,2,3,4-tetrahydro-β-carbolines via Fisher indole cyclisation.An alkaloid from Alstonia venenata is prepared.All compounds inclusive strychnocarpine show low affinity to the serotonine receptor. - Key words: 3-Hydroxy-2-pyridone, Strychnocarpine Derivatives, 5-Hydroxytryptamine Receptor Stimulators