1246087-81-9

Upstream product

• 130017-60-6 N-(4-chloro-7-methoxyquinazolin-6-yl)acetamide 
• 2840-26-8 3-amino-4-methoxybenzoic acid 
• 130017-51-5 3-acetamido-4-methoxybenzoic acid 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 
• 456-42-8 m-fluorobenzyl chloride 
• 619-08-9 2-chloro-4-nitrophenol 
• 202197-26-0 3-chloro-4-(3-fluorobenzyloxy)aniline 
• 443882-99-3 3-chloro-4-(3-fluorobenzyloxy)nitrobenzene 
• 162012-69-3 7-fluoro-6-nitro-4-hydroxyquinazoline 
• 162012-70-6 4-chloro-7-fluoro-6-nitroquinazoline 

Relevant academic research and scientific papers

1,2-DITHIOLANE AND DITHIOL COMPOUNDS USEFUL IN TREATING MUTANT EGFR-MEDIATED DISEASES AND CONDITIONS

Compositions of the invention comprise 1,2-dithiolane, dithiol and related compounds useful as therapeutic agents for the treatment and prevention of diseases and conditions associated with aberrant EGFR activity.

QUINAZOLINE DERIVATIVE AND PREPARATION METHOD THEREFOR

The present invention relates to a quinazoline derivative shown in formula (I) and a preparation method therefor, a pharmaceutical composition comprising the compound shown in formula (I), and an application of the compound in preparing drugs for curing and preventing tumors. The compound of the present invention can irreversibly prevent EGFR phosphorylation, and effectively depress signal transduction of cancer cells, and accordingly has higher anti-tumor activity in vitro and in vivo,

AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE THEREOF

Provided herein are aminoquinazoline compounds, salts and uses thereof. The compounds have Formula (I), or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug ther