1246523-46-5

Upstream product

• 1246523-45-4 methyl 2-(4-(2-azido-3-tert-butoxyphenyl)-6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-1H-indol-2-yl)-2-(4-methoxyphenyl)acetate 
• 1269631-74-4 7-(tert-butoxy)-5-methoxy-3-(4-methoxyphenethyl)-1,4-bis(4-methoxyphenyl)-3,6-dihydropyrrolo[2,3-c]carbazole 
• 14425-64-0 4-methoxyphenethyl bromide 
• 1246523-41-0 4-bromo-6-methoxy-3,7-bis-(4-methoxy-phenyl)-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester 
• 1246523-40-9 1-(1-(2,6-dibromo-4-methoxyphenyl)-2-nitroethyl)-4-methoxybenzene 
• 1246523-39-6 tert-butyl 2-(2,6-dibromo-4-methoxyphenyl)-2-(4-methoxyphenyl)ethylcarbamate 
• 1246523-38-5 4-bromo-6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-1H-indole 
• 1246523-56-7 tert-butyl 2-tert-butoxy-6-iodophenylcarbamate 
• 1246523-55-6 tert-butyl [2-(tert-butoxy)-6-iodophenyl]carbamate 
• 1246523-54-5 tert-butyl [2-(tert-butoxy)phenyl]carbamate 
• 1246523-53-4 methyl 2-(6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indol-2-yl)-2-(4-methoxyphenyl)acetate 
• 1246523-52-3 methyl 2-(4-bromo-6-methoxy-1-(4-methoxyphenethyl)-3,7-bis(4-methoxyphenyl)-1H-indol-2-yl)-2-(4-methoxyphenyl)acetate 
• 1246523-51-2 4-bromo-6-methoxy-3,7-bis-(4-methoxy-phenyl)-1H-indole 

Downstream Products

• 1246523-57-8 methyl 2-(7-hydroxy-5-methoxy-3-(4-methoxyphenethyl)-1,4-bis(4-methoxyphenyl)-3,6-dihydropyrrolo[2,3-c]carbazol-2-yl)-2-(4-methoxyphenyl)acetate 
• 1246523-47-6 methyl 2-(5-methoxy-3-(4-methoxyphenethyl)-1,4-bis(4-methoxyphenyl)-7-(2,2,2-trichloroethoxysulfonyloxy)-3,6-dihydropyrrolo[2,3-c]carbazol-2-yl)-2-(4-methoxyphenyl)acetate 
• 1246523-58-9 methyl 2-(5-hydroxy-3-(4-hydroxyphenethyl)-1,4-bis(4-hydroxyphenyl)-7-(2,2,2-trichloroethoxysulfonyloxy)-3,6-dihydropyrrolo[2,3-c]carbazol-2-yl)-2-(4-methoxyphenyl)acetate 
• 1246657-85-1 dictyodendrin A 

Relevant academic research and scientific papers

Total Synthesis of Dictyodendrins A–F by the Gold-Catalyzed Cascade Cyclization of Conjugated Diyne with Pyrrole

The total synthesis of dictyodendrins A–F was achieved by using the gold(I)-catalyzed annulation of a conjugated diyne with N-Boc-pyrrole for direct construction of the pyrrolo[2,3-c]carbazole scaffold. Late-stage functionalization of the resulting pyrrolo[2,3-c]carbazole to introduce various substituents provided divergent access to dictyodendrins. Some dictyodendrin analogues exhibited inhibitory activities toward CDK2/CycA2 and GSK3.

Total synthesis of dictyodendrins A-E

A highly efficient total synthesis of dictyodendrins A-E was accomplished. The synthesis features a novel benzyne-mediated one-pot indoline formation/cross-coupling sequence for the construction of a highly substituted key indoline intermediate. Peripheral substituents were introduced onto this intermediate in a modular fashion to complete the total synthesis of dictyodendrins A-E. A benzyne-mediated one-pot indoline formation/cross-coupling sequence is used for the construction of a highly substituted common indole intermediate. The peripheral substituents were introduced using a Friedel-Crafts reaction on the indole intermediate in a modular fashion to complete the total synthesis. Copyright

Total synthesis of dictyodendrin A and B

(Figure Presented) In-do-line of fire: A highly efficient total synthesis of the title compounds features a novel benzyne-mediated one-pot indoline formation/cross-coupling sequence for the construction of a highly substituted key indoline intermediate. The peripheral substituents were then introduced onto the intermediate in a modular fashion to complete the total syntheses of dictyodendrin A and B.