1246655-00-4

Basic information

• Product Name: ethyl 5-(tert-butyldimethylsilyloxy)-1-(iodomethyl)-2-oxocyclohexanecarboxylate
• Synonyms: ethyl 5-(tert-butyldimethylsilyloxy)-1-(iodomethyl)-2-oxocyclohexanecarboxylate
• CAS NO: 1246655-00-4
• Molecular Weight: 440.394
• Mol File: 1246655-00-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 5-(tert-butyldimethylsilyloxy)-1-(iodomethyl)-2-oxocyclohexanecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-(tert-butyldimethylsilyloxy)-1-(iodomethyl)-2-oxocyclohexanecarboxylate(1246655-00-4)
• EPA Substance Registry System: ethyl 5-(tert-butyldimethylsilyloxy)-1-(iodomethyl)-2-oxocyclohexanecarboxylate(1246655-00-4)

Safety Data

• Hazardous Substances Data: 1246655-00-4(Hazardous Substances Data)

Upstream product

• 126931-29-1 4-((tert-butyldimethylsilyl)oxy)cyclohexan-1-ol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 55145-45-4 4-(tert-butyldimethylsilyloxy)cyclohexanone 
• 556-48-9 1,4-Cyclohexanediol 
• 75-11-6 diiodomethane 

Downstream Products

• 1246655-04-8 C₅₇H₉₆O₁₅Si₃ 

Relevant articles and documents

The Grob/Eschenmoser fragmentation of cycloalkanones bearing β-electron withdrawing groups: A general strategy to acyclic synthetic intermediates

Introduction of a β-electron withdrawing group to cycloalkanones allows facile C-C bond fragmentation. The reaction has been demonstrated with a large range of ring sizes, bearing various leaving and electron withdrawing groups, and using a variety of nitrogen and oxygen containing nucleophiles (>30 examples). The application of fragmentation products to the preparation of substituted γ-lactones has been demonstrated. Mechanistic studies are reported which are suggestive of a Grob/Eschenmoser type reaction.