1246949-39-2

Basic information

• Product Name: (3α,5α,11β,17ξ,22S,24S)-3,11-bis(benzyloxy)-24-methyl-22,25-epoxyfurostan-20-ol
• Synonyms: (3α,5α,11β,17ξ,22S,24S)-3,11-bis(benzyloxy)-24-methyl-22,25-epoxyfurostan-20-ol
• CAS NO: 1246949-39-2
• Molecular Weight: 642.92
• Mol File: 1246949-39-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (3α,5α,11β,17ξ,22S,24S)-3,11-bis(benzyloxy)-24-methyl-22,25-epoxyfurostan-20-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (3α,5α,11β,17ξ,22S,24S)-3,11-bis(benzyloxy)-24-methyl-22,25-epoxyfurostan-20-ol(1246949-39-2)
• EPA Substance Registry System: (3α,5α,11β,17ξ,22S,24S)-3,11-bis(benzyloxy)-24-methyl-22,25-epoxyfurostan-20-ol(1246949-39-2)

Safety Data

• Hazardous Substances Data: 1246949-39-2(Hazardous Substances Data)

Upstream product

• 1578266-58-6 (3α,5α,11β)-3,11-bis(benzyloxy)-20-oxopregn-16-en-21-yl acetate 
• 1578266-57-5 (3α,5α,11β)-3,11-bis(benzyloxy)-20-oxopregnane-17,21-diyldiacetate 
• 1578266-55-3 (3α,5α,11β)-3,11-bis(benzyloxy)-17,21-dihydroxypregnan-20-one 
• 1578266-53-1 (3R,5S,8S,9S,10S,11S,13S,14S)-3,11-bis(benzyloxy)-10,13-dimethylhexadecahydrodispiro[cyclopenta[a]phenanthrene-17,4′-[1,3]dioxolane-5′,4″-[1,3]dioxolane] 
• 116154-42-8 ( 3R,5S,8S,9S,10S,11S,13S,14S)-10,13-dimethylhexadecahydrodispiro[cyclopenta[a]phenanthrene-17,4′-[1,3]dioxolane-5′,4″-[1,3]dioxolane]-3,11-diol 
• 1578266-51-9 (3R,5S,8S,9S,10S,11S,13S,14S)-11-hydroxy-10,13-dimethylhexadecahydrodispiro[cyclopenta[a]phenanthrene-17,4′-[1,3]dioxolane-5′,4″-[1,3]dioxolan]-3-yl benzoate 
• 116105-55-6 (3S,5S,8S,9S,10S,11S,13S,14S)-10,13-dimethylhexadecahydrodispiro[cyclopenta[a]phenanthrene-17,4′-[1,3]-dioxolane-5′,4″-[1,3]dioxolane]-3,11-diol 
• 807-05-6 (8S,9S,10R,11S,13S,14S)-11-Hydroxy-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydrodispiro[cyclopenta[a]phenanthrene-17,4′-[1,3]dioxolane-5′,4″-[1,3]-dioxolan]-3(2H)-one 
• 50-23-7 HYDROCORTISONE 
• 915-35-5 hecogenin acetate 
• 4802-74-8 11-ketotigogenin 
• 467-55-0 hecogenin 
• 94284-08-9 (R)-3-hydroxy-2,3-dimethylbutanal 
• 73295-12-2 (S)-2,3-dimethyl-1,3-butanediol 

Relevant articles and documents

Synthesis of the antiproliferative agent hippuristanol and its analogues from hydrocortisone via Hg(II)-catalyzed spiroketalization: Structure-activity relationship

An efficient synthesis of hippuristanol (1), a marine-derived highly potent antiproliferative steroidal natural product, and nine closely related analogues has been accomplished from the commercially available hydrocortisone utilizing Hg(II)-catalyzed spi

Efficient synthetic approach to potent antiproliferative agent hippuristanol via Hg(II)-catalyzed spiroketalization

Figure Presented. The steroidal natural product hippuristanol targets eukaryotic translation initiation factor (eIF)4A which plays a pivotal role in translation in eukaryotic cells. Now an efficient synthesis of hippuristanol from 11-ketotigogenin is reported. The synthesis features a rapid construction of a spiroketal unit via Hg(OTf)2-catalyzed oxidation/ spiroketalization of the 3-alkyn-1,7-diol motif.