124707-80-8Relevant academic research and scientific papers
COPPER CATALYZED REDUCTIVE METALLATION OF A PROPARGYLIC EPOXIDE TO AN ALLENYL LITHIUM REAGENT
Alexakis, A.,Marek, I.,Mangeney, P.,Normant, J. F.
, p. 2391 - 2392 (1989)
Phenethynyl cyclohexene oxide undergoes a reductive metallation by BuLi and catalytic amount of CuI salt.The resulting allenyl lithium reagent reacts, then, normally, with various electrophiles.
Diastereoselective syn or anti opening of propargylic epoxides. Synthesis of α-allenic alcohols
Alexakis,Marek,Mangeney,Normant
, p. 1677 - 1696 (2007/10/02)
Propargylic epoxides easily react with Grignard reagents and catalytic amounts of copper(I) salt to afford α-allenic alcohols. The reaction is highly diastereoselective and its stereochemical outcome (syn or anti isomer) can be fully controlled. The syn d
