124782-04-3

Basic information

• Product Name: methyl (2S,3R)-3--2-hydroxy-4-phenylbutanoate
• Synonyms: methyl (2S,3R)-3--2-hydroxy-4-phenylbutanoate
• CAS NO: 124782-04-3
• Molecular Weight: 343.379
• Mol File: 124782-04-3.mol

Chemical Properties

• CAS DataBase Reference: methyl (2S,3R)-3--2-hydroxy-4-phenylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2S,3R)-3--2-hydroxy-4-phenylbutanoate(124782-04-3)
• EPA Substance Registry System: methyl (2S,3R)-3--2-hydroxy-4-phenylbutanoate(124782-04-3)

Safety Data

• Hazardous Substances Data: 124782-04-3(Hazardous Substances Data)

Upstream product

• 63219-70-5 N-(benzyloxycarbonyl)-D-phenylalaninal 
• 591-51-5 phenyllithium 
• 95105-20-7 (2S,3R)-3-amino-4-phenylbutane-1,2-diol 
• 152897-53-5 (2S,3R)-3-benzyloxycarbonylamino-2-hydroxy-4-phenyl-1-butanol 
• 152897-52-4 (S)-5-<(S)-2-phenyl-1-(N-tosylamino)ethyl>-1,3-dioxolane 
• 23402-69-9 lithium diphenylcuprate 
• 137028-93-4 (4R,5S)-4-benzyl-3-benzyloxycarbonyl-2,2-dimethyl-oxazolidine-5-carboxylic acid methyl ester 

Downstream Products

• 100564-98-5 (4R,5S)-4-benzyl-2-oxo-5-oxazolidinecarboxylic acid 
• 59969-65-2 (2S,3R)-3-benzyloxycarbonylamino-2-hydroxy-4-phenyl-butanoic acid 
• 144676-50-6 (2S,3R)-3-(Benzyloxycarbonylamino)-2-methylsulfonyloxy-4-phenylbutanoic Acid Methyl Ester 
• 137028-93-4 (4R,5S)-4-benzyl-3-benzyloxycarbonyl-2,2-dimethyl-oxazolidine-5-carboxylic acid methyl ester 
• 150744-82-4 (4R,5S)-4-benzyl-3-benzyloxycarbonyl-2,2-dimethyl-oxazolidine-5-carboxylic acid 
• 137028-94-5 (4R,5S)-4-benzyl-3-benzyloxycarbonyl-5-(chloromethyl)carbonyl-2,2-dimethyl-oxazolidine 
• 137028-95-6 (4'R,5'S)-4-(4'-benzyl-3'-benzyloxycarbonyl-2',2'-dimethyl-oxazolidine-5'-yl)-2-methoxycarbonyl-4-oxobutanoic acid methyl ester 
• 137028-96-7 (4'R,5'S)-4-(4'-benzyl-3'-benzyloxycarbonyl-2',2'-dimethyl-oxazolidine-5'-yl)-2-isobutyl-2-methoxycarbonyl-4-oxobutyric acid methyl ester 
• 144676-55-1 (2R,3R)-2-Azido-3-(benzyloxycarbonylamino)-4-phenylbutanoic Acid 
• 144676-53-9 (2R,3R)-2-Azido-3-(benzyloxycarbonylamino)-4-phenylbutanoic Acid Methyl Ester 
• 144676-38-0 epi-Aminodeoxybestatin 

Relevant articles and documents

Synthesis of methyl 3-amino-2-hydroxy-4-phenylbutanoates, important core intermediates for peptide mimics possessing biological activities

Core intermediates for the synthesis of anti-cancer agents, inhibitors of aminopeptidases and HIV proteases, 3-amino-2-hydroxy-4-phenylbutanoates were synthesized by using H-C(CN)2O-SiR3 as a key reagent.

Stereoselective synthesis of α-hydroxy-β-amino acid derivatives from β-hydroxy-γ,δ-unsaturated sulfilimine

The first report on the use of N-sulfinyl benzylcarbamate for the preparation of N-Cbz sulfilimine from the corresponding sulfoxide is reported. The sulfilimine moiety is utilized as an intramolecular nucleophile for the regio- and stereoselective heterofunctionalization of an alkene to furnish a bromo carbamate which is used as a key advanced intermediate in the synthesis of representative α-hydroxy-β-amino acid derivatives.

Ring opening of optically active cis-disubstituted aziridino alcohols: An enantiodivergent synthesis of functionalized amino alcohol derivatives

Ring-opening reactions of optically active cis-disubstituted aziridino alcohols have been investigated. Regio- and stereo-selective ring opening took place with internal and external nucleophiles. Unusual amino acids derivatives (14) and (15), the key synthetic intermediates for bestatin and related peptides, have been prepared. n.

An enantiodivergent synthesis of three β-amino alcohols: Preparation of key intermediates for bestatin and the related peptides

An enantiodivergent method for preparation of three β-amino alcohols and three 1,2-diamines has been developed starting with a chiral aziridine 1. Unusual amino acid derivatives 3 and 5, which are key synthetic intermediates for bestatin and the related peptides, have been prepared.