1247822-13-4Relevant articles and documents
Decarboxylative aldol reaction of α,α-difluoro-β-ketocarboxylate salt: A facile method for generation of difluoroenolate
Tarui, Atsushi,Oduti, Mayuna,Shinya, Susumu,Sato, Kazuyuki,Omote, Masaaki
, p. 20568 - 20575 (2018/06/14)
We developed a decarboxylative aldol reaction using α,α-difluoro-β-ketocarboxylate salt, carbonyl compounds, and ZnCl2/N,N,N′,N′-tetramethylethylenediamine. The generation of difluoroenolate proceeded smoothly under mild heating to provide α,α-
An expedient synthesis of α,α-difluoro-β-hydroxy ketones via decarboxylative aldol reaction of α,α-difluoro-β-keto acids with aldehydes
Huang, Da-Kang,Lei, Zhong-Liang,Zhu, Yu-Jun,Liu, Zhen-Jiang,Hu, Xiao-Jun,Mao, Hai-Fang
supporting information, p. 3394 - 3397 (2017/08/02)
A novel decarboxylative aldol reaction of α,α-difluoro-β-keto acids with aldehydes in the absence of any base and metal catalysts has been developed. This reaction provides a highly convenient and efficient method for the synthesis of structurally diverse α,α-difluoro-β-hydroxy ketones in good to excellent yields.
Synthesis of α,α-difluoro-β-hydroxy ketone via the La(OTf)3-catalyzed aldol reaction of carbonyl compounds with difluoroenol O-Boc esters
Sasaki, Shigeru,Suzuki, Tatuo,Uchiya, Toshihiro,Toyota, Shigenobu,Hirano, Akira,Tanemura, Mao,Teramoto, Hiroyoshi,Yamauchi, Takayasu,Higashiyama, Kimio
, p. 78 - 85 (2016/11/09)
We herein present an efficient method for the construction of α,α-difluoro-β-hydroxy ketones. The La(OTf)3-catalyzed aldol reaction between difluoroenol O-Boc (Boc?=?tert-butyloxycarbonyl) esters and carbonyl compounds affords α,α-difluoro-β-hy
