1248337-32-7

Upstream product

• 104-94-9 4-methoxy-aniline 
• 623-47-2 propynoic acid ethyl ester 
• 34780-29-5 3-oxo-propionic acid ethyl ester 

Downstream Products

• 1236203-51-2 diethyl 4-(2-ethoxy-2-oxoethyl)-1-(4-methoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate 
• 1248337-50-9 (R)-ethyl 1-(4-methoxyphenyl)-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate 
• 1248337-36-1 (S)-ethyl 1-(4-methoxyphenyl)-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate 
• 1256796-22-1 ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-1,6-dihydropyridine-3-carboxylate 
• 1256796-21-0 ethyl 1-(4-methoxyphenyl)-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate 

Relevant academic research and scientific papers

Green H 2 O-Promoted Solvent-Free Synthesis of Enaminocarbonyl Compounds with High Stereoselectivity from Electron-Deficient Terminal Alkynes

A green H 2 O-promoted solvent-free hydroamination of electron-deficient terminal alkynes with amines has been developed. All secondary amines, including aliphatic and aromatic amines, gave the corresponding (E)-enamines in good to excellent yi

Silica Gel as a Promoter of Sequential Aza-Michael/Michael Reactions of Amines and Propiolic Esters: Solvent- and Metal-Free Synthesis of Polyfunctionalized Conjugated Dienes

We present an efficient, simple, metal- and solvent-free silica-gel-promoted synthesis of functionalized conjugated dienes by sequential aza-Michael/Michael reactions by starting from commercially available primary amines and propiolic esters. The scope a

Catalytic asymmetric synthesis of both enantiomers of 4-substituted 1,4-Dihydropyridines with the use of bifunctional Thiourea-Ammonium salts bearing different counterions

Organoammonium salts composed of a Bronsted acid and an anilinothiourea promoted the Michael addition of β-keto esters and α,β-unsaturated aldehydes in the presence of primary amines to give functionalized 1,4-dihydropyridines enantioselectively. With the

Novel synthetic route to 1,4-dihydropyridines from β-amino acrylates by using titanium(IV) chloride under facile conditions

The reactions of Boc-β-amido- and β-amino acrylates, in which the C=C possesses both nucleophilic and electrophilic sites, were investigated under acidic conditions. The trifluoroacetic-acid induced cyclization of the β-amido acrylates to the corresponding oxazolidin-2-ones involves a rarely seen nucleophilic attack of the carbamate carbonyl group. The cyclotrimerization of 13-amino acrylates to N-substituted 1,4- dihydropyridines was observed in the presence of a Lewis acid. High yields of 1,4-dihydropyridines (7083%) were readily obtained by using substoichiometric amount TiCl4 under mild condition. The cyclotrimerization is presumably occurring via a Hantzsch related mechanism involving three addition/ elimination reactions of the amphiphilically reactive C=C.