1249-97-4

Usage

Uses

Used in Analytical Chemistry:
Benzoyl leuco methylene blue is used as a reaction indicator for detecting the endpoint of redox titrations. Its color change from colorless to blue in the presence of oxidizing agents allows for accurate determination of the endpoint, ensuring precise measurements and results.
Used in Chemical Reaction Monitoring:
Benzoyl leuco methylene blue is employed as a monitoring tool in various chemical reactions. Its ability to undergo a reversible reaction with oxygen and change color provides a visual indication of the progress of the reaction, allowing chemists to track the reaction's course and make necessary adjustments.
Used in Determining Compound Concentrations:
Benzoyl leuco methylene blue is utilized for determining the concentration of certain compounds in a sample solution. Its color change in response to the presence of oxidizing agents enables the quantification of specific compounds, providing valuable data for further analysis and research.

InChI:InChI=1/C23H23N3OS/c1-24(2)17-10-12-19-21(14-17)28-22-15-18(25(3)4)11-13-20(22)26(19)23(27)16-8-6-5-7-9-16/h5-15H,1-4H3

Upstream product

• 613-11-6 Leuco-Methylenblau 
• 98-88-4 benzoyl chloride 
• 152071-32-4 methylene blue 
• 4727-46-2 3,7-bis(dimethylamino)phenothiazin-5-ylium iodide 
• 92-84-2 10H-phenothiazine 

Downstream Products

• 152071-32-4 methylene blue 
• 807306-71-4 3,7-bis(dimethylamine)phenothiazonium 
• 65-85-0 benzoic acid 

Relevant academic research and scientific papers

Release of Amino- or Carboxy-Containing Compounds Triggered by HOCl: Application for Imaging and Drug Design

The overproduction of HOCl is highly correlated with diseases such as atherosclerosis, rheumatoid arthritis, and cancer. Whilst acting as a marker of these diseases, HOCl might also be used as an activator of prodrugs or drug delivery systems for the treatment of the corresponding disease. In this work, a new platform of HOCl probes has been developed that integrates detection, imaging, and therapeutic functions. The probes can detect HOCl, using both NIR emission and the naked eye in vitro, with high sensitivity and selectivity at ultralow concentrations (the detection limit is at the nanomolar level). Basal levels of HOCl can be imaged in HL-60 cells without special stimulation. Moreover, the probes provided by this platform can rapidly release either amino- or carboxy-containing compounds from prodrugs, during HOCl detection and imaging, to realize a therapeutic effect.

METHOD FOR PREPARING 3,7-BIS(DIMETHYLAMINO)PHENOTHIAZIN-5-YLIUM IODIDE

Method for preparing 3,7-bis(dimethylamino)phenothiazin-5-ylium iodide, the method resulting in a high purity while being very simple to implement and producing high yields. The method uses phenothiazine as a starting material and includes the following steps: a) treating phenothiazine with diiodine, b) treating the reaction medium directly obtained from step a) with dimethylamine.

PROCESS FOR THE PREPARATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS HAVING A HIGH DEGREE OF PURITY

A process for the preparation of diaminophenothiazinium compounds is described, which allows achieving quickly and effectively a high degree of purity of the same.

PROCESS FOR PREPARING DIAMINOPHENOTHIAZINIUM COMPOUNDS

Process for preparing compounds of the diaminophenothiazinium type comprising a step for purification of derivatives (II). The products resulting from this process have a high degree of purity. Use of these compounds for the preparation of medicaments.

Action of Sodium Dithionite on Some Cationic Dyes

Sodium dithionite (SDT) has been developed as a useful reagent to dequaternize a variety of cationic dyes.Triarylmethane dyes are converted into leuco bases; however, hemicyanines smoothly undergo dehydrochlorination.Phenothiazine and phenoxazine dyes on reduction with SDT give unstable leuco bases, which can be isolated as their N-benzoyl derivatives.The IR, PMR and mass spectral studies of the leuco bases or the dequaternized products have been found to be useful for structure elucidation of the cationic dyes.