124909-09-7

Upstream product

• 186581-53-3 diazomethane 
• 124990-12-1 (S)-(+)-2-methyl-2-(4-methylphenyl)butanedioic acid 
• 127047-04-5 dimethyl 2-methyl-2-(4-methylphenyl)malonate 
• 127047-09-0 (S)-3-Methoxycarbonyloxy-2-methyl-3-oxo-2-p-tolyl-propionic acid methyl ester 
• 133678-88-3 (R)-(+)-methyl 2-methyl-2-(4-methylphenyl)-3-(tosyloxy)propionate 
• 133678-79-2 (S)-(+)-methyl 3-cyano-2-methyl-2-(4-methylphenyl)propionate 
• 877077-49-1 (R)-(+)-2-(methoxycarbonyl)-2-(4-methylphenyl)propionic acid 
• 127047-07-8 (R)-(+)-methyl 3-hydroxy-2-methyl-2-(4-methylphenyl)propionate 
• 79443-97-3 methyl 2-(4-methylphenyl)propanoate 
• 67-56-1 methanol 
• 133678-80-5 (R)-(+)-methyl 4-diazo-2-methyl-2-(4-methylphenyl)-3-oxobutanoate 

Downstream Products

• 124909-11-1 dimethyl-2,3,3-trimethyl-2-(4-methylphenyl)succinate 
• 124909-16-6 (S)-2,3-Dimethyl-2-p-tolyl-succinic acid dimethyl ester 

Relevant academic research and scientific papers

Asymmetric Construction of Quaternary Carbons from Chiral Malonates: Selective and Versatile Total Syntheses of the Enantiomers of α- and β-Cuparenones from a Common Optically Active Precursor

From a single chiron (R)-4, available with high enantiomeric purity (96percent) by simple enzymatic hydrolysis (PLE) of a prochiral malonate, were prepared convenient precursors of the two enantiomers of α- and β-cuparenones (1a,b and 2a,b).This versatile

TOTAL SYNTHESIS OF (R)-(-)-β-CUPARENONE

(R)-(-)-β-Cuparenone has been synthesized from (S)-(+)-acid-2 obtained via resolution of the racemic acid.Two of the noteworthy steps are (a) repeated methylation of ester (+)-8 with LDA/MeI to furnish (+)-10 and (b) the reaction of 12, having two neopent