125038-99-5Relevant articles and documents
Two-Step Catalytic Transformation of N-Benzyllactams to Alkaloids (±)-Solenopsin, (±)-Solenopsin A, and (+)-Julifloridine
Ou, Wei,Lu, Guang-Sheng,An, Dong,Han, Feng,Huang, Pei-Qiang
supporting information, p. 52 - 56 (2019/12/27)
We report herein that the Ir and CuI bis-metal catalyzed reductive alkynylation of amides, a method that we developed previously, can be extended to 6-, 7-, and 8-membered lactams. The catalytic reductive alkynylation of 6-methyl-2-piperidinone
Elemental-Sulfur-Incorporated Cyclizations of Pyrrolidines Leading to Thienopyrroles
Yue, Yuanyuan,Shao, Huibin,Wang, Zhixian,Wang, Ke,Wang, Le,Zhuo, Kelei,Liu, Jianming
, p. 11265 - 11279 (2020/10/12)
We report, herein, the synthesis of thieno[3,2-b]pyrroles from the direct oxidative [4 + 1] cyclization of 2-alkynyl pyrrolidines with elemental sulfur. This transformation likely originates from electrophilic attack at the β-position of pyrrolidine follo
Copper-catalyzed aerobic decarboxylative coupling between cyclic α-amino acids and diverse C-H nucleophiles with low catalyst loading
Guo, Jing,Xie, Ying,Wu, Qiao-Lei,Zeng, Wen-Tian,Chan, Albert S. C.,Weng, Jiang,Lu, Gui
, p. 16202 - 16206 (2018/05/22)
An aerobic decarboxylative cross-coupling of α-amino acids with diverse C-H nucleophiles has been realized using Cu2(OH)2CO3 (1 mol%) as the catalyst under air. This protocol enables highly efficient formation of various C
Redox-neutral copper(II) carboxylate catalyzed α-alkynylation of amines
Das, Deepankar,Sun, Aaron X.,Seidel, Daniel
supporting information, p. 3765 - 3769 (2013/04/24)
Cocktail of three: A new strategy for iminium ion isomerization was applied to the direct, redox-neutral α-alkynylation of amines. Copper(II) 2-ethylhexanoate [Cu(2-EH)2] was identified as the optimal catalyst for this three-component coupling reaction of secondary amines, aldehydes, and alkynes. MW=microwave. Copyright
Aldehyde- and ketone-induced tandem decarboxylation-coupling (Csp 3-Csp) of natural α-amino acids and alkynes
Bi, Hai-Peng,Teng, Qingfeng,Guan, Min,Chen, Wen-Wen,Liang, Yong-Min,Yao, Xiaojun,Li, Chao-Jun
supporting information; experimental part, p. 783 - 788 (2010/04/28)
(Chemical Equation Presented) An interesting aldehyde- and ketone-induced intermolecular tandem decarboxylation-coupling (Csp3-Csp) catalyzed by copper with use of natural α-amino acids as starting materials is developed under neutral condition
The copper-catalyzed decarboxylative coupling of the sp3- hybridized carbon atoms of α-amino acids
Bi, Hai-Peng,Zhao, Liang,Liang, Yong-Min,Li, Chao-Jun
supporting information; experimental part, p. 792 - 795 (2009/05/06)
(Chemical Equation Presented) Joined at the Cs: A novel intermolecular decarboxylative Csp3-Csp3, Csp3-C sp2, and Csp3-Csp coupling catalyzed by CuBr and using a-amino acids as starting materials has
Alkynylation of Thiolactams. New Synthesis of α-Substituted Pyrrolidine and Piperidine Alkaloids
Takahata, Hiroki,Takahashi, Koichi,Wang, Eng-Chi,Yamazaki, Takao
, p. 1211 - 1214 (2007/10/02)
Alkynylation of S-alkylthioamidium salts of thiolactams with lithium acetylides followed by reduction with LiAlH4 provided α-alkynylazacycloalkanes, which on reduction, or hydroboration followed by oxidation, gave α-substituted pyrrolidine and piperidine alkaloids.