125080-05-9

Upstream product

• 60-29-7 diethyl ether 
• 141-52-6 sodium ethanolate 
• 5292-53-5 diethyl benzalmalonate 
• 7152-15-0 ethyl 4-methyl-3-oxo-pentanoate 
• 100-52-7 benzaldehyde 
• 29509-06-6 4-methyl-3-oxopentanonitrile 

Downstream Products

• 872269-62-0 5-methyl-4-oxo-2-phenyl-hexane-1,1,3-tricarboxylic acid triethyl ester 
• 533883-19-1 ethyl 2-[2-(4-fluorophenyl)-2-oxo-1-phenyl-ethyl]-4-methyl-3-oxopentanoate 

Relevant academic research and scientific papers

PROCESS FOR PREPARING C5 INTERMEDIATES AND THEIR USE IN THE PREPARATION OF N-SUBSTITUTED PYRROLE DERIVATIVES

The present invention relates to a process for preparing C5 intermediates and their use in the preparation of pyrrole derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, and more particularly to improved synthetic methods for preparing 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids from 1,4-diketo starting materials. The invention further relates to intermediates in this process.

Process for preparing pyrrole derivatives and intermediates

The present invention relates to a process for preparing pyrrole derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, and more particularly to improved synthetic methods for preparing 3,5-dihydroxy-7-pyrrol-1-y

Process for preparing C5 products and their use for Atorvastatin synthesis

The present invention relates to a process for preparing C5 intermediates and their use in the preparation of pyrrole derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, and more particularly to improved synthetic methods for preparing 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids from 1,4-diketo starting materials. The invention further relates to intermediates in this process

A new route to 2-alkenyl-1,3-dicarbonyl compounds, intermediates in the synthesis of dihydrofurans

A two step synthetic strategy for obtaining 2-alkenyl-1,3-dicarbonyl compounds from the corresponding 1,3-dicarbonyl compounds is reported. The method is based on a Knoevenagel condensation and a Michael addition using a high order organocuprate procedure, and proves to be of general value. Obtained compounds are useful starting materials for the synthesis of furan derivatives.