1251529-11-9

Basic information

• Product Name: 1-[1-(4-chloro-3-methyl-benzyl)-piperidin-4-yl]-5-oxo-pyrrolidine-2-carboxylic acid
• Synonyms: 1-[1-(4-chloro-3-methyl-benzyl)-piperidin-4-yl]-5-oxo-pyrrolidine-2-carboxylic acid
• CAS NO: 1251529-11-9
• Molecular Weight: 350.845
• Mol File: 1251529-11-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-[1-(4-chloro-3-methyl-benzyl)-piperidin-4-yl]-5-oxo-pyrrolidine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[1-(4-chloro-3-methyl-benzyl)-piperidin-4-yl]-5-oxo-pyrrolidine-2-carboxylic acid(1251529-11-9)
• EPA Substance Registry System: 1-[1-(4-chloro-3-methyl-benzyl)-piperidin-4-yl]-5-oxo-pyrrolidine-2-carboxylic acid(1251529-11-9)

Safety Data

• Hazardous Substances Data: 1251529-11-9(Hazardous Substances Data)

Upstream product

• 41661-47-6 piperidin-4-one 
• 117890-58-1 4-(bromomethyl)-1-chloro-2-methylbenzene 
• 1251529-07-3 1-(4-chloro-3-methyl-benzyl)-piperidin-4-one 
• 1251529-08-4 C₂₃H₃₅ClN₂O₄ 
• 1251529-09-5 C₁₉H₂₇ClN₂O₄ 
• 13515-99-6 D-glutamic acid dimethyl ester hydrochloride 
• 41979-39-9 4-piperidone hydrochloride 
• 1251529-10-8 C₁₉H₂₅ClN₂O₃ 
• 92304-76-2 1-chloro-4-(chloromethyl)-2-methylbenzene 

Downstream Products

• 1251526-16-5 C₂HF₃O₂*C₂₆H₃₀ClN₇O₂ 
• 1251526-20-1 C₂HF₃O₂*C₂₇H₃₀ClF₃N₄O₃ 
• 1251526-24-5 C₂₃H₂₈ClN₅O₄S 
• 1251529-47-1 C₂₇H₃₅ClN₄O₄S 
• 1251527-67-9 C₂₆H₃₁ClN₄O₄ 
• 1251527-64-6 C₂₆H₃₁ClN₄O₄ 
• 1251528-23-0 C₂₇H₃₄ClN₅O₃ 
• 1372127-17-7 C₁₈H₁₄O₈*C₂₇H₃₄ClN₅O₃ 
• 1462983-50-1 C₂₇H₃₄ClN₅O₃*ClH 

Relevant articles and documents

PROCESS FOR THE MANUFACTURING OF CCR3 INHIBITORS

The present invention relates to a process for preparing CCR3 inhibitors of formula (1), wherein R1 is H, C1-6-alkyl, C0-4-alkyl-C3-6-cycloalkyl, C1-6-haloalkyl; R2 is H, C1-6-alkyl; Xis an anion selected from the group consisting of chloride or ? dibenzoyltartrate; j is 1 or 2.

CO-CRYSTALS AND SALTS OF CCR3-INHIBITORS

This invention relates to co-crystals and salts of CCR3 inhibitors of formula 1, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases related with the CCR3-receptor.

SUBSTITUTED PIPERIDINES AS CCR3 ANTAGONISTS

Object of the present invention are novel substituted compounds of the formula 1, wherein A, R1, R2, R3 and R4 are defined as in the description. Another object of the present invention is to provide antagonists of CCR3, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.