125218-53-3

Upstream product

• 137530-20-2 Methanesulfonic acid (R)-2-cyclohexyl-1-((S)-5-oxo-tetrahydro-furan-2-yl)-ethyl ester 
• 21461-84-7 (2S)-tetrahydro-5-oxofuran-2-carboxylic acid 
• 136944-72-4 (S)-5-((R)-2-Cyclohexyl-1-hydroxy-ethyl)-dihydro-furan-2-one 
• 137271-77-3 ((4S,5R)-5-Cyclohexylmethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-methanol 
• 16666-81-2 cyclohexyltriphenylphosphorane 
• 122840-75-9 (3aR,5S,6aR)-5-((S)-1-Azido-2-cyclohexyl-ethyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxole 
• 122840-94-2 (3R,5S)-5-((S)-1-Azido-2-cyclohexyl-ethyl)-2-methoxy-tetrahydro-furan-3-ol 
• 122854-68-6 (R)-2-Cyclohexyl-1-((3aR,5S,6aR)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethanol 
• 2457-93-4 (3aR,5S,6aR)-2,2-dimethyl-5-[(2R)-oxiran-2-yl]-3a,5,6,6a-tetrahydrofuro[2,3-d] [1,3]dioxole 
• 137530-19-9 (5S,1'S)-5-(2'-cyclohexyl-1'-hydroxyethyl)dihydrofuran-2(3H)-one 
• 137530-20-2 (5S,1'S)-5-(2'-cyclohexyl-1'-methanesulfonyloxyethyl)dihydrofuran-2(3H)-one 
• 137530-18-8 (S)-5-(2'-cyclohexyl-1'-oxoethyl)dihydrofuran-2(3H)-one 
• 54848-33-8 (S)-tetrahydro-5-oxo-2-furancarbonyl chloride 
• 137530-21-3 (5S,1'R)-5-(1'-bromo-2'-cyclohexylethyl)dihydrofuran-2(3H)-one 

Downstream Products

• 132094-22-5 (3R,5S,1'S)-5-(1'-tert-butoxycarbonylamino-2'-cyclohexylethyl)-3-methyldihydrofuran-2(3H)-one 
• 112227-09-5 (5S)-5-[(1S)-1-(N-t-butoxycarbonylamino)-2-cyclohexylethyl]dihydrofuran-2(3H)-one 

Relevant academic research and scientific papers

Studies of HIV-1 protease inhibitors. II. Incorporation of four types of hydroxyethylene dipeptide isosteres at the scissile site of substrate sequences

Human immunodeficiency virus type 1 (HIV-1) protease inhibitors containing four types of hydroxyethylene dipeptide isosteres were designed and synthesized. These inhibitors consist of eight stereoisomers of phenylalanylproline (Phe-Ψ[H.E.]-Pro), four ster

A new enantioseletive synthesis of (4S, 5S)-5-(N-Boc)-amino-6-cyclohexyl-4-hydroxy-hexanoic acid lactone, a hydroxyethylene dipeptide isostere precursor

A new enantioselective synthesis of a valuable hydroxyethylene dipeptide isostere precursor, (4S,5S)-5-(N-Boc)-amino-6-cyclohexyl-4-hydroxy-hexanoic acid lactone, has been developed by using coupling reaction of chiral triflates as a key step.

Synthesis of Statine and Its Analogues

Statine, (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid, and its analogues were prepared from 5,6-anhydro-3-deoxy-1,2-O-isopropylidene-D-glucofuranose.The key step is the stereospecific reaction of the epoxy sugar with the Grignard reagent.