137530-20-2

Upstream product

• 137530-18-8 (S)-5-(2'-cyclohexyl-1'-oxoethyl)dihydrofuran-2(3H)-one 
• 54848-33-8 (S)-tetrahydro-5-oxo-2-furancarbonyl chloride 
• 21461-84-7 (2S)-tetrahydro-5-oxofuran-2-carboxylic acid 
• 124-63-0 methanesulfonyl chloride 
• 137530-19-9 (5S,1'S)-5-(2'-cyclohexyl-1'-hydroxyethyl)dihydrofuran-2(3H)-one 
• 137271-78-4 Trifluoro-methanesulfonic acid (4S,5R)-5-cyclohexylmethyl-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester 
• 137271-79-5 3-((4S,5R)-5-Cyclohexylmethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-propionic acid tert-butyl ester 
• 137271-77-3 ((4S,5R)-5-Cyclohexylmethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-methanol 
• 16666-81-2 cyclohexyltriphenylphosphorane 
• 136944-72-4 (S)-5-((R)-2-Cyclohexyl-1-hydroxy-ethyl)-dihydro-furan-2-one 

Downstream Products

• 132094-22-5 (3R,5S,1'S)-5-(1'-tert-butoxycarbonylamino-2'-cyclohexylethyl)-3-methyldihydrofuran-2(3H)-one 
• 112227-09-5 (5S)-5-[(1S)-1-(N-t-butoxycarbonylamino)-2-cyclohexylethyl]dihydrofuran-2(3H)-one 
• 125218-53-3 (5S,1'S)-5-(1'-azido-2'-cyclohexylethyl)dihydrofuran-2(3H)-one 
• 137530-21-3 (5S,1'R)-5-(1'-bromo-2'-cyclohexylethyl)dihydrofuran-2(3H)-one 

Relevant academic research and scientific papers

Studies of HIV-1 protease inhibitors. II. Incorporation of four types of hydroxyethylene dipeptide isosteres at the scissile site of substrate sequences

Human immunodeficiency virus type 1 (HIV-1) protease inhibitors containing four types of hydroxyethylene dipeptide isosteres were designed and synthesized. These inhibitors consist of eight stereoisomers of phenylalanylproline (Phe-Ψ[H.E.]-Pro), four ster

A new enantioseletive synthesis of (4S, 5S)-5-(N-Boc)-amino-6-cyclohexyl-4-hydroxy-hexanoic acid lactone, a hydroxyethylene dipeptide isostere precursor

A new enantioselective synthesis of a valuable hydroxyethylene dipeptide isostere precursor, (4S,5S)-5-(N-Boc)-amino-6-cyclohexyl-4-hydroxy-hexanoic acid lactone, has been developed by using coupling reaction of chiral triflates as a key step.