1253116-75-4Relevant academic research and scientific papers
Greener synthesis of 1,2,3-triazoles using a copper(i)-exchanged magnetically recoverable β-zeolite as catalyst
Andrade, Floyd C. D.,Costa, Elizama R.,De Albuquerque, Danilo Yano,Ferreira, Luanne E. M.,Lima, Carolina G. S.,Lima, Thiago M.,Paix?o, Márcio W.,Schwab, Ricardo S.,Silva, Domingos S. A.,Urquieta-González, Ernesto A.
, p. 15046 - 15053 (2020/10/02)
Herein, we describe the preparation and thorough characterization of a novel magnetically recoverable copper(i)-exchanged β-zeolite and its use as an efficient catalyst for the synthesis of 1,2,3-triazoles via the one-pot three-component reaction of organic halides, terminal acetylenes, and sodium azide in water. The magnetically recoverable β-zeolite could be easily separated from the reaction mixture with the aid of a magnet and reused in several consecutive reactions. Importantly, a series of characterizations studies allowed us to disclose the mechanism for the deactivation of the catalyst, and therefore to propose a method for its reactivation.
Copper-Catalyzed Oxidative Cross-Dehydrogenative Coupling/Oxidative Cycloaddition: Synthesis of 4-Acyl-1,2,3-Triazoles
Liu, Yi,Nie, Gang,Zhou, Zhongzhen,Jia, Lihui,Chen, Yunfeng
, p. 9198 - 9203 (2017/09/11)
A copper-catalyzed three-component reaction of methyl ketones, organic azides, and various one-carbon (C1) donors was developed that provides 4-acyl-1,2,3-triazoles in moderate to good yields. While DMF, DMA, TMEDA, or DMSO can serve as the C1 donor, best yields were obtained using DMF. The transformation is proposed to proceed via an oxidative C-H/C-H cross-dehydrogenative coupling followed by an oxidative 1,3-dipolar cycloaddition.
Promotion of 1,3-dipolar cycloaddition between azides and β-enaminones by deep eutectic solvents
Martins, Marcos Antonio Pinto,Paveglio, Guilherme Caneppele,Rodrigues, Leticia Valvassori,Frizzo, Clarissa Piccinin,Zanatta, Nilo,Bonacorso, Helio Gauze
, p. 5989 - 5992 (2016/07/19)
A simple procedure to obtain 4-acyl-1-substituted-1,2,3-triazoles, using a deep eutectic solvent (DES), ChCl and ethylene glycol at a 1:2 ratio, as the reaction medium is described. The products were obtained in high selectivity and good yields (70-84%).
An efficient and high-yielding one-pot synthesis of 4-acyl-1,2,3-triazoles via triisopropylsilyl-protected ynones
Hwang, Soonho,Bae, Hoon,Kim, Sanghee,Kim, Sumin
experimental part, p. 1460 - 1465 (2012/03/08)
A practical and efficient process has been developed for the synthesis of 1-substituted 4-acyl-1H-1,2,3-triazoles using a three-step one-pot synthetic approach. This transformation involves an initial preparation of triisopropylsilyl (TIPS)-protected ynon
One-pot three-step synthesis of 1,2,3-triazoles by copper-catalyzed cycloaddition of azides with alkynes formed by a Sonogashira cross-coupling and desilylation
Friscourt, Frederic,Boons, Geert-Jan
supporting information; experimental part, p. 4936 - 4939 (2010/12/25)
A microwave-assisted, one-pot, three-step Sonogashira cross-coupling- desilylation-cycloaddition sequence was developed for the convenient preparation of 1,4-disubstituted 1,2,3-triazoles starting from a range of halides, acyl chlorides, ethynyltrimethyls
