503595-78-6

Upstream product

• 7099-91-4 p-methoxybenzoylformic acid 
• 181934-30-5 1-[(triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one 
• 123-11-5 4-methoxy-benzaldehyde 
• 89343-06-6 tris-iso-propylsilyl acetylene 
• 107474-02-2 1-(triisopropylsilyl)-2-(trimethylsilyl)acetylene 
• 105-13-5 4-Methoxybenzyl alcohol 
• 100-07-2 4-methoxy-benzoyl chloride 

Downstream Products

• 1253116-75-4 (1-benzyl-1H-1,2,3-triazol-4-yl)(4'-methoxyphenyl)methanone 
• 503595-98-0 [1-(4-Methoxy-phenyl)-3-triisopropylsilanyl-prop-2-yn-(Z)-ylidene]-phenylethynyl-amine 
• 503595-90-2 1-(4-methoxyphenyl)-3-(triisopropylsilyl)prop-2-yn-1-one oxime mesylate 

Relevant academic research and scientific papers

Decarboxylative Alkynylation of α-Keto Acids and Oxamic Acids in Aqueous Media

A mild K2S2O8 promoted decarboxylative alkynylation of α-keto acids and oxamic acids has been developed. This process features mild reaction conditions, a broad substrate scope, and good functional-group tolerance, therefo

Highly Regioselective and E/ Z-Selective Hydroalkylation of Ynone, Ynoate, and Ynamide via Photoredox Mediated Ni/Ir Dual Catalysis

Exclusively α- and highly E/Z-selective hydroalkylation of ynone, ynoate, and ynamide was achieved via photoredox mediated Ni/Ir dual catalysis with high atom and step economy, producing trisubstituted enones, which are versatile synthetic building blocks. The developed reaction selectively delivered the α/Z isomer, which is complementary to the previously reported β-alkylation processes. The trisubstituted enones could be transformed to more valuable compounds via post-functionalization.

Metal-free synthesis of ynones via direct C-H alkynylation of aldehydes with ethynylbenziodoxolones

Abstract A metal-free synthesis of ynones via direct alkynlyation of C-H bonds in aldehydes with ethynylbenziodoxolones is described. A variety of unactivated aldehydes undergo this transformation, affording ynones in good yields. These ynones could be fu

Metal-free carbonyl C(sp2)-H oxidative alkynylation of aldehydes using hypervalent iodine reagents leading to ynones

A new metal-free tert-butyl hydroperoxide (TBHP)-mediated carbonyl C(sp2)-H oxidative alkynylation of aldehydes with ethynyl benziodoxolones (EBX) for the synthesis of ynones is described. This method is based on a carbonyl C(sp2)-H

Transition-Metal-Free Synthesis of Ynones via Decarboxylative Alkynylation of α-Keto Acids under Mild Conditions

A transition-metal-free synthetic method of various ynones via decarboxylative alkynylation of α-keto acids is described. The reaction is carried out under mild conditions and exhibits remarkable tolerance of functional groups. The mechanism of a radical

An efficient and high-yielding one-pot synthesis of 4-acyl-1,2,3-triazoles via triisopropylsilyl-protected ynones

A practical and efficient process has been developed for the synthesis of 1-substituted 4-acyl-1H-1,2,3-triazoles using a three-step one-pot synthetic approach. This transformation involves an initial preparation of triisopropylsilyl (TIPS)-protected ynon

An extremely facile aza-Bergman rearrangement of sterically unencumbered acyclic 3-aza-3-ene-1,5-diynes

The factors that affect the kinetics of the aza-Bergman cyclization of aza-enediynes (C,N-dialkynyl imines) have not previously been elucidated. Here we report our kinetic studies of the aza-Bergman reactions of a series of 6-triisopropylsilyl and 6-unsub